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Chinese Optics Letters

Chinese Optics Letters


  • Vol. 3, Iss. 12 — Dec. 10, 2005
  • pp: 705–707

Raman spectroscopic identification of normal and malignant human stomach cells

Jipeng Yang, Jianyu Guo, Liangping Wu, Zhenrong Sun, Weiying Cai, and Zugeng Wang  »View Author Affiliations

Chinese Optics Letters, Vol. 3, Issue 12, pp. 705-707 (2005)

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Micro-Raman spectroscopy is employed to identify the normal and malignant human stomach cells. For the cancer cell, the reduced intensity of the Raman peak at 1250 cm^(-1) indicates that the protein secondary structure transforms from ?-sheet or disordered structures to ?-helical, while the increased intensity of the symmetric PO2 stretching vibration mode at 1094 cm^(-1) shows the increased DNA content. The ratio of the intensity at 1315 cm^(-1) to that at 1340 cm^(-1) reduces from 1.8 for the normal cell to 1.1 for the cancer cell in the course of canceration, and the ratio of the intensity at 1655 cm^(-1) to that at 1450 cm^(-1) increases from 1.00 for the cancer cell to 1.26 for the normal cell which indicates that the canceration of stomach cell may induce saturation of the lipid chain.

© 2005 Chinese Optics Letters

OCIS Codes
(170.0170) Medical optics and biotechnology : Medical optics and biotechnology
(170.1530) Medical optics and biotechnology : Cell analysis
(170.5660) Medical optics and biotechnology : Raman spectroscopy
(300.6450) Spectroscopy : Spectroscopy, Raman

Jipeng Yang, Jianyu Guo, Liangping Wu, Zhenrong Sun, Weiying Cai, and Zugeng Wang, "Raman spectroscopic identification of normal and malignant human stomach cells," Chin. Opt. Lett. 3, 705-707 (2005)

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