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Chinese Optics Letters

Chinese Optics Letters

| PUBLISHED MONTHLY BY CHINESE LASER PRESS AND DISTRIBUTED BY OSA

  • Vol. 3, Iss. 5 — May. 10, 2005
  • pp: 289–291

Effects of different levels of vitamin C on UV radiation-induced DNA damage

Dianfeng Zhou, Hang Heng, Kang Ji, and Weizhong Ke  »View Author Affiliations


Chinese Optics Letters, Vol. 3, Issue 5, pp. 289-291 (2005)


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Abstract

The Raman spectra of DNA in different levels of vitamin C with 10- and 30-min ultraviolet (UV) radiations were reported. The intensity of UV radiation was 18.68 W/m2. The experimental results proved that vitamin C could alone prevent UV radiation from damaging DNA, but the effects depended on the concentration of vitamin C. When the concentration of vitamin C was about 0.08-0.4 mmol/L, vitamin C decreased UV radiation-induced DNA's damage. When the concentration of vitamin C exceeded 0.4 mmol/L, vitamin C accelerated DNA's damage instead. Maybe the reason is that when DNA in aqueous solution is radiated by UV, free radicals come into being, and vitamin C can scavenge free radicals, so vitamin C in lower concentration can protect DNA. The quantity of free radicals is finite, when vitamin C is superfluous, free radicals have been scavenged absolutely and vitamin C is residual. Vitamin C is a strong reductant. When the mixture of DNA and residual vitamin C is radiated by UV, vitamin C reacts with DNA. The more residual vitamin C and the longer time of UV radiation, the more DNA is damaged.

© 2005 Chinese Optics Letters

OCIS Codes
(300.6170) Spectroscopy : Spectra
(300.6390) Spectroscopy : Spectroscopy, molecular
(300.6450) Spectroscopy : Spectroscopy, Raman

Citation
Dianfeng Zhou, Hang Heng, Kang Ji, and Weizhong Ke, "Effects of different levels of vitamin C on UV radiation-induced DNA damage," Chin. Opt. Lett. 3, 289-291 (2005)
http://www.opticsinfobase.org/col/abstract.cfm?URI=col-3-5-289


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