Based on the generalized pulse spectrum technique that was previously developed for time-domain diffuse optical tomography, we propose a linear framework of time-domain fluorescence molecular tomography for simultaneous reconstruction of both the yield and lifetime of multi-fluorophores. The methodology is exemplified for mono-component case and validated with simulated data.
© 2006 Chinese Optics Letters
(170.3010) Medical optics and biotechnology : Image reconstruction techniques
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.5280) Medical optics and biotechnology : Photon migration
Feng Gao, Wei Liu, and Huijuan Zhao, "Linear scheme for time-domain fluorescence molecular tomography," Chin. Opt. Lett. 4, 595-597 (2006)