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Chinese Optics Letters

Chinese Optics Letters

| PUBLISHED MONTHLY BY CHINESE LASER PRESS AND DISTRIBUTED BY OSA

  • Editor: Zhizhan Xu
  • Vol. 4, Iss. 2 — Feb. 10, 2006
  • pp: 101–104

Study on the interaction of anticancer drug mitoxantrone with DNA by fluorescence and Raman spectroscopies

Lingjuan Tang, Zhenrong Sun, Jianyu Guo, and Zugeng Wang  »View Author Affiliations


Chinese Optics Letters, Vol. 4, Issue 2, pp. 101-104 (2006)


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Abstract

Mitoxantrone, a clinically useful antitumour antibiotic for leukaemia and breast cancer, has received more attentions. In this paper, the interaction between mitoxantrone and calf thymus DNA is investigated by Raman and fluorescence spectroscopies, and the binding site of mitoxantrone to calf thymus DNA is explored. The results showed that mitoxantrone interacts with calf thymus DNA bases by the intercalation of anthracycline into the base pair plane of adenine (A) and thymine (T), and it results in the disruption of the hydrogen bonds between calf thymus DNA bases, and thus the calf thymus DNA double-strand can be disrupted into the B-form DNA double-strand segments.

© 2005 Chinese Optics Letters

OCIS Codes
(000.1430) General : Biology and medicine
(170.0170) Medical optics and biotechnology : Medical optics and biotechnology
(170.5660) Medical optics and biotechnology : Raman spectroscopy
(300.6450) Spectroscopy : Spectroscopy, Raman

Citation
Lingjuan Tang, Zhenrong Sun, Jianyu Guo, and Zugeng Wang, "Study on the interaction of anticancer drug mitoxantrone with DNA by fluorescence and Raman spectroscopies," Chin. Opt. Lett. 4, 101-104 (2006)
http://www.opticsinfobase.org/col/abstract.cfm?URI=col-4-2-101

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