Expand this Topic clickable element to expand a topic
Skip to content
Optica Publishing Group
  • Chinese Optics Letters
  • Vol. 4,
  • Issue 2,
  • pp. 101-104
  • (2006)

Study on the interaction of anticancer drug mitoxantrone with DNA by fluorescence and Raman spectroscopies

Not Accessible

Your library or personal account may give you access

Abstract

Mitoxantrone, a clinically useful antitumour antibiotic for leukaemia and breast cancer, has received more attentions. In this paper, the interaction between mitoxantrone and calf thymus DNA is investigated by Raman and fluorescence spectroscopies, and the binding site of mitoxantrone to calf thymus DNA is explored. The results showed that mitoxantrone interacts with calf thymus DNA bases by the intercalation of anthracycline into the base pair plane of adenine (A) and thymine (T), and it results in the disruption of the hydrogen bonds between calf thymus DNA bases, and thus the calf thymus DNA double-strand can be disrupted into the B-form DNA double-strand segments.

© 2005 Chinese Optics Letters

PDF Article
More Like This
A fluorescent reporter on electrostatic DNA-ligand interactions

Chandrashekhar U. Murade and George T. Shubeita
Biomed. Opt. Express 13(1) 159-167 (2022)

Quantitative analysis of double-stranded DNA amplified by a polymerase chain reaction employing surface-enhanced Raman spectroscopy

X. Dou, T. Takama, Y. Yamaguchi, K. Hirai, H. Yamamoto, S. Doi, and Y. Ozaki
Appl. Opt. 37(4) 759-763 (1998)

A simple and rapid detection of tissue adhesive-induced biochemical changes in cells and DNA using Raman spectroscopy

Gyeong Bok Jung, Young Ju Lee, Gihyun Lee, and Hun-Kuk Park
Biomed. Opt. Express 4(11) 2673-2682 (2013)

Cited By

You do not have subscription access to this journal. Cited by links are available to subscribers only. You may subscribe either as an Optica member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access Optica Member Subscription

Select as filters


Select Topics Cancel
© Copyright 2024 | Optica Publishing Group. All Rights Reserved