OSA's Digital Library

Chinese Optics Letters

Chinese Optics Letters

| PUBLISHED MONTHLY BY CHINESE LASER PRESS AND DISTRIBUTED BY OSA

  • Editor: Zhizhan Xu
  • Vol. 4, Iss. 2 — Feb. 10, 2006
  • pp: 101–104

Study on the interaction of anticancer drug mitoxantrone with DNA by fluorescence and Raman spectroscopies

Lingjuan Tang, Zhenrong Sun, Jianyu Guo, and Zugeng Wang  »View Author Affiliations


Chinese Optics Letters, Vol. 4, Issue 2, pp. 101-104 (2006)


View Full Text Article

Acrobat PDF (283 KB)





Browse Journals / Lookup Meetings

Browse by Journal and Year


   


Lookup Conference Papers

Close Browse Journals / Lookup Meetings

Article Tools

Share
Citations
  • Export Citation/Save Click for help

Abstract

Mitoxantrone, a clinically useful antitumour antibiotic for leukaemia and breast cancer, has received more attentions. In this paper, the interaction between mitoxantrone and calf thymus DNA is investigated by Raman and fluorescence spectroscopies, and the binding site of mitoxantrone to calf thymus DNA is explored. The results showed that mitoxantrone interacts with calf thymus DNA bases by the intercalation of anthracycline into the base pair plane of adenine (A) and thymine (T), and it results in the disruption of the hydrogen bonds between calf thymus DNA bases, and thus the calf thymus DNA double-strand can be disrupted into the B-form DNA double-strand segments.

© 2005 Chinese Optics Letters

OCIS Codes
(000.1430) General : Biology and medicine
(170.0170) Medical optics and biotechnology : Medical optics and biotechnology
(170.5660) Medical optics and biotechnology : Raman spectroscopy
(300.6450) Spectroscopy : Spectroscopy, Raman

Citation
Lingjuan Tang, Zhenrong Sun, Jianyu Guo, and Zugeng Wang, "Study on the interaction of anticancer drug mitoxantrone with DNA by fluorescence and Raman spectroscopies," Chin. Opt. Lett. 4, 101-104 (2006)
http://www.opticsinfobase.org/col/abstract.cfm?URI=col-4-2-101


Sort:  Author  |  Year  |  Journal  |  Reset

References

  1. D. W. Pang and H. D. Abruna, Analytical Chemistry 72, 4700 (2000).
  2. A. Erdem and M. Ozsoz, Analytica Chimica Acta 437, 107 (2001).
  3. H. Morjani, J. F. Riou, I. Nabiev, F. Lavelle, and M. Manfait, Cancer Research 53, 4784 (1993).
  4. J. M. Le Gal, H. Morjani, and M. Manfaint, Cancer Research 53, 3681 (1993).
  5. F. Seela and Y. Chen, Nucleic Acids Research 23, 2499 (1995).
  6. K. M. Guckian, T. R. Krugh, and E. T. Kool, Nature Structural Biology 5, 954 (1998).
  7. F. G. Loontiens, L. W. McLaughlin, S. Diekmann, and R. M. Clegg, Biochemistry 30, 182 (1991).
  8. J. A. Neidhart, D. Gochnour, and R. A. Roach, Journal of Clinical Oncology 4, 672 (1986).
  9. F. Brito-Babapulle, D. Catovsky, G. Slocombe, A. C. Newland, R. E. Marcus, J. M. Goldman, and D. A. Galton, Cancer Treatment Reports 71, 161 (1987).
  10. Y. A. Mao, W. Z. Wei, and S. F. Zhang, Anal. Bioanal. Chem. 373, 215 (2002).
  11. S. F. Wang, T. Z. Peng, and C. F. Yang, Biophys. Chem. 104, 239 (2003).
  12. H. Deng, V. A. Bloomfield, J. M. Benevides, and G. J. Thomas, Biopolymers 50, 656 (1999).
  13. E. Kocisova, L. Chinsky, and P. Miskovsky, Journal of Biomolecular Structure & Dynamics 15, 1147 (1998).
  14. T. Akira, H. Naoki, O. Junko, Y. Emiko, and T. Hideo, Journal of Raman Spectroscopy 30, 623 (1999).
  15. R. Dong, X. Yan, X. Pang, and S. Liu, Spectrochimica Acta Part A 60, 557 (2004).
  16. J. R. Chica, M. A. Medina, F. S. Jimenez, and F. J. Ramirez, Biochimica et Biophysica Acta 1628, 11 (2003).
  17. P. Yang, M. L. Guo, and B. S. Yang, Chin. Sci. Bulletin (in Chinese) 38, 2049 (1993).
  18. Q. S. Li, P. Yang, H. F. Wang, and M. L. Guo, Journal of Inorganic Biochemistry 64, 181 (1996).
  19. V. E. Semenov, V. D. Akamsin, V. S. Reznik, A. V. Chernova, G. M. Dorozhkina, Y. Y. Efremov, and A. A. Nafikova, Tetrahedron Lett. 43, 9683 (2002).
  20. W. J. Jin, Y. S. Wei, C. S. Liu, G. L. Shen, and R. Q. Yu, Spectrochimica Acta Part A 53, 2701 (1997).
  21. C.-W. Ong, Inorganica Chimica Acta 123, 221 (1986).
  22. Y. Ye, J. M. Hu, and Y. Zeng, Inorganica Chimica Acta 16, 6 (2000).

Cited By

OSA is able to provide readers links to articles that cite this paper by participating in CrossRef's Cited-By Linking service. CrossRef includes content from more than 3000 publishers and societies. In addition to listing OSA journal articles that cite this paper, citing articles from other participating publishers will also be listed.

« Previous Article  |  Next Article »

OSA is a member of CrossRef.

CrossCheck Deposited