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Optica Publishing Group
  • Chinese Optics Letters
  • Vol. 6,
  • Issue 12,
  • pp. 889-892
  • (2008)

Experimental validation for time-domain fluorescence diffuse optical tomography of linear scheme

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Abstract

We present a full three-dimensional, featured-data algorithm for time-domain fluorescence diffuse optical tomography that inverts the Laplace-transformed time-domain coupled diffusion equations and employs a pair of appropriate transform-factors to effectively separate the fluorescent yield and lifetime parameters. By use of a time-correlation single-photon counting system and the normalized Born formulation, we experimentally validate that the proposed scheme can achieve simultaneous reconstruction of the fluorescent yield and lifetime distributions with a reasonable accuracy.

© 2008 Chinese Optics Letters

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