Raman spectroscopic identification of normal and malignant hepatocytes
Chinese Optics Letters, Vol. 7, Issue 1, pp. 60-63 (2009)
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Abstract
Raman spectroscopy has strong potential for providing non-invasion diagnosis of cancers. In this paper, micro-Raman spectroscopy is used to diagnose one most common liver cancer, hepatocellular carcinoma (HCC). The statistical analyzes, including t-test, principal component analysis (PCA), and linear discriminant analysis (LDA), are performed on the Raman spectra of malignant and normal hepatocytes. The t-test-LDA results show that the 786- and 1004-cm^{-1} bands of the malignant and normal hepatocytes are significantly different, and PCA-LDA results show an overall accuracy of 100% for the Raman spectroscopic identification of normal and malignant hepatocytes in our experiment.
© 2009 Chinese Optics Letters
OCIS Codes
(170.1530) Medical optics and biotechnology : Cell analysis
(170.5660) Medical optics and biotechnology : Raman spectroscopy
(300.6450) Spectroscopy : Spectroscopy, Raman
Citation
Jianyu Guo, Bing Du, Min Qian, Weiying Cai, Zugeng Wang, and Zhenrong Sun, "Raman spectroscopic identification of normal and malignant hepatocytes," Chin. Opt. Lett. 7, 60-63 (2009)
http://www.opticsinfobase.org/col/abstract.cfm?URI=col-7-1-60
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