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Chinese Optics Letters

Chinese Optics Letters

| PUBLISHED MONTHLY BY CHINESE LASER PRESS AND DISTRIBUTED BY OSA

  • Vol. 8, Iss. 10 — Oct. 1, 2010
  • pp: 940–943

Uptake of transferrin-conjugated quantum dots in single living cells

Danni Chen, Gaixia Xu, Bahi Ahmed Ali, Ken-Tye Yong, Cuihong Zhou, Xiaomei Wang, Junle Qu, Paras N. Prasad, and Hanben Niu  »View Author Affiliations


Chinese Optics Letters, Vol. 8, Issue 10, pp. 940-943 (2010)


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Abstract

We study the uptake and distribution of transferrin (Tf)-conjugated CdSe/CdS/ZnS quantum dots (QDs) in single living HeLa cells with both fluorescence confocal microscopy and three-dimensional (3D) reconstruction technique. By increasing the co-incubation time or the dosage of QDs-Tf, we find that the uptake of QDs-Tf bioconjugates in the cells increases correspondingly, but with different uptake rates. Additionally, the distribution of QDs-Tf, in single live HeLa cells is time dependent. To our knowledge, this is the first study on quantitatively analyzing the uptake and distribution of bioconjugated QDs in single living cells. Such QDs nanoplatform can be further modified for developing biomedical evaluation tool in cancer diagnosis and targeted drug delivery.

© 2010 Chinese Optics Letters

OCIS Codes
(170.1530) Medical optics and biotechnology : Cell analysis
(170.6280) Medical optics and biotechnology : Spectroscopy, fluorescence and luminescence

Citation
Danni Chen, Gaixia Xu, Bahi Ahmed Ali, Ken-Tye Yong, Cuihong Zhou, Xiaomei Wang, Junle Qu, Paras N. Prasad, and Hanben Niu, "Uptake of transferrin-conjugated quantum dots in single living cells," Chin. Opt. Lett. 8, 940-943 (2010)
http://www.opticsinfobase.org/col/abstract.cfm?URI=col-8-10-940

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