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Chinese Optics Letters

Chinese Optics Letters

| PUBLISHED MONTHLY BY CHINESE LASER PRESS AND DISTRIBUTED BY OSA

  • Vol. 8, Iss. 10 — Oct. 1, 2010
  • pp: 950–952

Confocal imaging of Bim translocation to endoplasmic reticulum during DHA-induced ASTC-a-1 cell apoptosis

Min Chen, Yingying Lu, Tongsheng Chen, and Junle Qu  »View Author Affiliations


Chinese Optics Letters, Vol. 8, Issue 10, pp. 950-952 (2010)


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Abstract

Bim, a proapoptotic member of Bcl-2 family, plays an important role in cell apoptosis. It is generally thought that Bim translocates to mitochondria in response to apoptotic stimuli. We use confocal microscopy to image the temporal-spatial dynamics of Bim during dihydroartemisinin (DHA) induced human lung adenocarcinoma (ASTC-a-1) cell apoptosis. Interestingly, we find that DHA induces Bim translocation to endoplasmic reticulum (ER) rather than mitochondria, implying that Bim-ER pathway might be involved in the DHA-induced ASTC-a-1 cell apoptosis.

© 2010 Chinese Optics Letters

OCIS Codes
(170.1530) Medical optics and biotechnology : Cell analysis
(170.1790) Medical optics and biotechnology : Confocal microscopy
(170.2655) Medical optics and biotechnology : Functional monitoring and imaging

Citation
Min Chen, Yingying Lu, Tongsheng Chen, and Junle Qu, "Confocal imaging of Bim translocation to endoplasmic reticulum during DHA-induced ASTC-a-1 cell apoptosis," Chin. Opt. Lett. 8, 950-952 (2010)
http://www.opticsinfobase.org/col/abstract.cfm?URI=col-8-10-950

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