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Chinese Optics Letters

Chinese Optics Letters

| PUBLISHED MONTHLY BY CHINESE LASER PRESS AND DISTRIBUTED BY OSA

  • Vol. 8, Iss. 11 — Nov. 1, 2010
  • pp: 1075–1078

Fluorescence molecular tomography system for in vivo tumor imaging in small animals

Jianwei Fu, Xiaoquan Yang, Guotao Quan, and Hui Gong  »View Author Affiliations


Chinese Optics Letters, Vol. 8, Issue 11, pp. 1075-1078 (2010)


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Abstract

A fluorescence molecular tomography system for <i>in vivo</i> tumor imaging is developed using a 748-nm continuous wave diode laser as an excitation source. A high sensitivity cooled charge-coupled device (CCD) camera with excitation and emission filters is utilized to obtain the excitation and fluorescence images. The laser beam performs fast raster scanning using a dual-axis galvanometric scanner. The accuracy of the laser spot position at the source window is within ±200 µm. Based on the phantom experimental results, the spatial resolution is less than 1.7 mm, and the relative quantitation error is about 10%. <i>in vivo</i> imaging of a tumor-bearing nude mouse tagged with near-infrared dye demonstrates the feasibility of the system.

© 2010 Chinese Optics Letters

OCIS Codes
(170.0110) Medical optics and biotechnology : Imaging systems
(170.6280) Medical optics and biotechnology : Spectroscopy, fluorescence and luminescence
(170.6960) Medical optics and biotechnology : Tomography

Citation
Jianwei Fu, Xiaoquan Yang, Guotao Quan, and Hui Gong, "Fluorescence molecular tomography system for in vivo tumor imaging in small animals," Chin. Opt. Lett. 8, 1075-1078 (2010)
http://www.opticsinfobase.org/col/abstract.cfm?URI=col-8-11-1075


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