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Chinese Optics Letters

Chinese Optics Letters


  • Vol. 8, Iss. 3 — Mar. 1, 2010
  • pp: 309–312

Tagged molecule induced nanoparticle aggregation:Raman reporter-labeled immuno-Au aggregate as immuno-sensor

Chunyuan Song, Zhuyuan Wang, Ruohu Zhang, Jing Yang, Xuebin Tan, and Yiping Cui  »View Author Affiliations

Chinese Optics Letters, Vol. 8, Issue 3, pp. 309-312 (2010)

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A novel structure with high surface enhanced Raman scattering (SERS) activity and bio-specificity as a SERS-based immuno-sensor (named as Raman reporter-labeled immuno-Au aggregate) is demonstrated and employed for protein detection. In each fabrication process, the features of those aggregates are obtained and characterized by ultraviolet-visible (UV-Vis) extinction spectra, transmission electron microscopy (TEM) images, scanning electron microscopy (SEM) pictures, and SERS spectra. Experimental results indicate that proper amounts of the reporter molecules can result in the moderate aggregation morphologies of gold nanoparticles. Compared with the previously reported method using Raman reporterlabeled immuno-Au nanoparticles, more sensitive SERS-based protein detection is realized with this novel immuno-sensor.

© 2010 Chinese Optics Letters

OCIS Codes
(290.5860) Scattering : Scattering, Raman
(300.6450) Spectroscopy : Spectroscopy, Raman
(160.4236) Materials : Nanomaterials

Chunyuan Song, Zhuyuan Wang, Ruohu Zhang, Jing Yang, Xuebin Tan, and Yiping Cui, "Tagged molecule induced nanoparticle aggregation:Raman reporter-labeled immuno-Au aggregate as immuno-sensor," Chin. Opt. Lett. 8, 309-312 (2010)

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