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Journal of Lightwave Technology

Journal of Lightwave Technology


  • Vol. 16, Iss. 4 — Apr. 1, 1998
  • pp: 583–

Integrated Optical Mach-Zehnder Biosensor

B. J. Luff, James S. Wilkinson, Jacob Piehler, Uwe Hollenbach, Jan Ingenhoff, and Norbert Fabricius

Journal of Lightwave Technology, Vol. 16, Issue 4, pp. 583- (1998)

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We present measurements on biomolecular surface multilayers using an integrated optical sensor based on the Mach-Zehnder interferometer (MZI). The sensor design is unique in that it incorporates a three-waveguide coupler structure at the interferometer output which gives advantages in terms of signal referencing and in establishing and maintaining a sensitive operating point. The sensor performance is characterized with respect to bulk superstrate index and by the formation of multiple protein adlayers using a biotin-avidin-based biochemical system. The detection limit for protein loading is estimated as 5 pg/mm2.


B. J. Luff, James S. Wilkinson, Jacob Piehler, Uwe Hollenbach, Jan Ingenhoff, and Norbert Fabricius, "Integrated Optical Mach-Zehnder Biosensor," J. Lightwave Technol. 16, 583- (1998)

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  1. B. J. Luff, R. D. Harris, J. S. Wilkinson, R. Wilson and D. J. Schiffrin, "Integrated optical directional coupler biosensor," Optics Lett., vol. 21, pp. 618-620, 1996.

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