The performance of an interferometric device based on integrated Bimodal Waveguides (BiMW) for sensing is demonstrated. The sensors are fabricated using standard silicon technology and can achieve a detection limit of 2.5 · 10-7 RIU for homogeneous sensing, rendering in a very high sensitive device. The applicability of the bimodal waveguide interferometer as label-free biosensor has been demonstrated by the real-time monitoring of the biomolecular interaction of BSA and antiBSA. Due to their simplicity, the interferometric devices could be further integrated in complete lab-on-a-chip platforms for point-of-care diagnostics showing them as a powerful instrument for biochemical analysis.
© 2011 IEEE
Kirill E. Zinoviev, Ana Belén González-Guerrero, Carlos Domínguez, and Laura M. Lechuga, "Integrated Bimodal Waveguide Interferometric Biosensor for Label-Free Analysis," J. Lightwave Technol. 29, 1926-1930 (2011)