Expand this Topic clickable element to expand a topic
Skip to content
Optica Publishing Group
  • Journal of Lightwave Technology
  • Vol. 32,
  • Issue 20,
  • pp. 3768-3773
  • (2014)

Quantitative Mapping of Pharmaceutical Cocrystals Within Cellulose by Terahertz Spectroscopy

Not Accessible

Your library or personal account may give you access

Abstract

Terahertz (THz) spectroscopy is a powerful tool for identifying inter-molecular hydrogen bonds in pharmaceutical materials. Here, we present quantitative chemical imaging of multicomponent pellets composed of pharmaceutical cocrystals and cellulose by THz spectroscopy. The stabilized THz time-domain spectroscope with laser beam monitoring and feedback supports accurate absorption spectra measurement. The linearity of THz absorptions of cocrystals and cellulose against the concentration are experimentally verified. In addition, the concentrations of the materials inside pellets are quantitatively extracted and mapped from the THz spectroscopic image by linear regression using reference THz spectra obtained for cocrystals and diluents.

© 2014 IEEE

PDF Article
More Like This
Terahertz notch filter using intermolecular hydrogen bonds in a sucrose crystal

Rakchanok Rungsawang, Yuko Ueno, Isao Tomita, and Katsuhiro Ajito
Opt. Express 14(12) 5765-5772 (2006)

Chemometrics applied quantitative analysis of iron oxide mixtures by terahertz spectroscopy

Ying Li, Tian-Yao Zhang, Zhao-Hui Zhang, Jian-Feng Yan, Xuan Zhao, Xiao-Yan Zhao, Xing-Yue Li, Xian-Hao Wu, Lu Yin, Yuan Yuan, and Jian-Mei Guo
Appl. Opt. 62(5) 1167-1174 (2023)

CW-THz vector spectroscopy and imaging system based on 1.55-µm fiber-optics

Jae-Young Kim, Ho-Jin Song, Makoto Yaita, Akihiko Hirata, and Katsuhiro Ajito
Opt. Express 22(2) 1735-1741 (2014)

Cited By

You do not have subscription access to this journal. Cited by links are available to subscribers only. You may subscribe either as an Optica member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access Optica Member Subscription

Select as filters


Select Topics Cancel
© Copyright 2024 | Optica Publishing Group. All Rights Reserved