OSA's Digital Library

Journal of the Optical Society of America

Journal of the Optical Society of America

  • Vol. 70, Iss. 1 — Jan. 1, 1980
  • pp: 53–59

Frequency-domain analysis of the human electroretinogram

Moshe Gur and Yehoshua Zeevi  »View Author Affiliations


JOSA, Vol. 70, Issue 1, pp. 53-59 (1980)
http://dx.doi.org/10.1364/JOSA.70.000053


View Full Text Article

Acrobat PDF (925 KB)





Browse Journals / Lookup Meetings

Browse by Journal and Year


   


Lookup Conference Papers

Close Browse Journals / Lookup Meetings

Article Tools

Share
Citations

Abstract

Normal corneal electroretinograms (ERG) are analyzed in the frequency domain using the fast Fourier transform (FFT) and linear prediction (LP) methods. Four dominant frequencies at 18, 79, 126, and 159 Hz are found in the dark-adapted state. Light adaptation shifts the low frequency to higher frequency and the mid- and the two high-frequency components to lower frequencies. The relative amplitude of the high-frequency component resulting from the oscillatory potentials is quantified. It is shown that frequency-domain features are of a smaller variability than time-domain components, and can be extracted even from a noisy surface ERG.

© 1980 Optical Society of America

Citation
Moshe Gur and Yehoshua Zeevi, "Frequency-domain analysis of the human electroretinogram," J. Opt. Soc. Am. 70, 53-59 (1980)
http://www.opticsinfobase.org/josa/abstract.cfm?URI=josa-70-1-53


Sort:  Author  |  Year  |  Journal  |  Reset

References

  1. J. C. Armington, The Electroretinogram (Academic, New York, 1974).
  2. A. E. Krill, Hereditary Retinal and Choroidal Diseases (Harper and Row, New York, 1972), Vol. I.
  3. G. A. Fishman, The Electroretinogram and Electro-oculogram in Retinal and Choroidal Disease (American Academy of Ophthalmology and Otolarylngology, Minneapolis, 1975).
  4. H. Peterson, "The normal b-potential in the single-flash clinical electroretinogram," Acta Ophthalmol. Suppl. 101, 1–57 (1969).
  5. P. Algvere and S. Westbeck, "Human ERG in response to double flashes of light during the course of light adaptation: a Fourier analysis of the oscillatory potentials," Vision Res. 12, 145–214 (1972).
  6. A. J. Koblasz, "Nonlinear analysis of the human electroretinogram," Ph.D. thesis, California Institute of Technology, California,1977 (unpublished).
  7. C. McCulloch, J. A. Orpin, J. W. Waisberg, and J. A. Parker, "Frequency analysis of the human dark adapted electroretinogram," Canad. J. Ophthalmol. 7, 189–198 (1974).
  8. R. E. Poppele and L. Maffei, "Frequency analysis of the electroretinogram," J. Neurophysiol. 30, 982–992 (1967).
  9. J. L. Rae, M. J. Correia, Ni, M-D, and A. J. Koblasz, "Frequency domain characterization of the human electroretinogram using gaussian white noise," ARVO, p. 194 (1978).
  10. A. Troelstra and N. M. J. Schweitzer, "An analysis of the b-wave in the human ERG," Vision Res. 3, 213–226 (1963).
  11. A. Troelstra and N. M. J. Schweitzer, "Non-linear analysis of the electroretinographic b-wave in man," J. Neurophysiol. 31, 588–606 (1968).
  12. L. H. Zetterberg, "Estimation of parameters for a linear difference equation with application to EEG analysis," Math. Biosci. 5, 227–274 (1969).
  13. M. Gjotterberg, "Double flash human electroretinogram with special reference to the oscillatory potentials and the early phase of dark adaptation: A normative study," Acta Ophthalmol. 52, 291–303 (1974).
  14. S. E. Simonson, "ERG in diabetics," in The Clinical Value of Electroretinography, edited by J. Francois (ISCERG Symposium, Ghent, 1966). (Karger, New York, 1968), pp. 403–412.
  15. E. Usami, "Studies on the method of measurement of oscillatory potential on ERG," Acta Soc. Ophthalmol. Jpn. 70, 84–91 (1965).
  16. A. Harden, "Non-corneal electroretinogram," Brit. J. Ophthalmol. 58, 811–816 (1974).
  17. J. W. Cooley, P. A. W. Lewis and P. D. Welch, "The fast Fourier transform," IEEE Trans. Audio Electroacoust. 17, 77–85 (1969).
  18. R. G. Bickford, P. T. White, C. W. Sem-Jacobson, and E. A. Rodin, "Components of the photomyoclonic response in man," Fed. Proc. 12, 15 (1953).
  19. J. Makhoul, "Linear prediction: A tutoral review," Proc. IEEE 63, 561–580 (1975).
  20. We denote the sampled normalized signal by S(n) and assume that it can be estimated by a linear combination of its past values: S(n) = - pΣk=1akS(n - k). Using the z transform we get the following all-pole model: H(z) = 1/1 + pΣk=1akz-k. In order to find the required model of the signal one has to determine the set of p coef., |ak|. The estimated spectrum is accordingly equal to: P(w) = 1/│1 + pΣk=1ake-jkw│2. The signal is thus characterized by the set of p poles and the dominant frequencies are selected with respect to their absolute value which is a measure of the quality factor.
  21. J. C. Armington, P. Gouras, D. I. Tepas, and R. Gunkel, "Detection of the electroretinogram in retinitis pigmentosa," Exp. Eye Res. 1, 74–80 (1961).
  22. Y. M. Lee, Statistical Theory of Communication (Wiley, New York, 1961).
  23. L. Stark, Neurological Control Systems - Studies in Bioengineering (Plenum, New York, 1968).
  24. L. Ronchi, "Some questions concerning electroretinographic response and its variability," Med. Res. Eng. 12, 20–24 (1978).
  25. D. Yonemura, T. Aoki and K. Tsuzuki, "Electroretinogram in diabetic retinopathy," Arch. Ophthalmol. 68, 14–24 (1962).
  26. P. Algvere, "Studies on the oscillatory potentials of the clinical electroretinogram," Acta Ophthalmol. Suppl. 96, 11 (1968).
  27. L. Wachtmeister and J. Dowling, "The oscillatory potentials of the mudpuppy retina," Invest. Ophthalmol. Visual Sci. 12, 1177–1188 (1978).
  28. Since eye movements are conjugate, one could record from both eyes while simulating only one eye. Since the record from the stimulated eye would contain ERG plus artifacts while the record from the other, covered eye would contain only artifacts, one could eliminate the common element either by simple subtraction or by more sophisticated methods such as cross correlation or adaptive filtering.
  29. J. H. Jacobson, T. Suzuki, and G. Stephens, "The electroretinogram obtained by computer techniques in color-deficient humans," Arch. Ophthalmol. 69, 424–435 (1963).
  30. K. Y. Fujimara, I Tsuchida, and J. H. Jacobson, "Oscillatory potential of the human electroretinogram evoked by monochromatic light," Invest. Ophthalmol. 4, 683–693 (1972).

Cited By

Alert me when this paper is cited

OSA is able to provide readers links to articles that cite this paper by participating in CrossRef's Cited-By Linking service. CrossRef includes content from more than 3000 publishers and societies. In addition to listing OSA journal articles that cite this paper, citing articles from other participating publishers will also be listed.

« Previous Article  |  Next Article »

OSA is a member of CrossRef.

CrossCheck Deposited