OSA's Digital Library

Journal of the Optical Society of America A

Journal of the Optical Society of America A


  • Vol. 20, Iss. 10 — Oct. 1, 2003
  • pp: 1841–1851

Optical aberrations of intraocular lenses measured in vivo and in vitro

Sergio Barbero, Susana Marcos, and Ignacio Jiménez-Alfaro  »View Author Affiliations

JOSA A, Vol. 20, Issue 10, pp. 1841-1851 (2003)

View Full Text Article

Acrobat PDF (1014 KB)

Browse Journals / Lookup Meetings

Browse by Journal and Year


Lookup Conference Papers

Close Browse Journals / Lookup Meetings

Article Tools



Corneal and ocular aberrations were measured in a group of eyes before and after cataract surgery with spherical intraocular lens (IOL) implantation by use of well-tested techniques developed in our laboratory. By subtraction of corneal from total aberration maps, we also estimated the optical quality of the intraocular lens in vivo. We found that aberrations in pseudophakic eyes are not significantly different from aberrations in eyes before cataract surgery or from previously reported aberrations in healthy eyes of the same age. However, aberrations in pseudophakic eyes are significantly higher than in young eyes. We found a slight increase of corneal aberrations after surgery. The aberrations of the IOL and the lack of balance of the corneal spherical aberrations by the spherical aberrations of the intraocular lens also degraded the optical quality in pseudophakic eyes. We also measured the aberrations of the IOL in vitro, using an eye cell model, and simulated the aberrations of the IOL on the basis of the IOL’s physical parameters. We found a good agreement among in vivo, in vitro, and simulated measures of spherical aberration: Unlike the spherical aberration of the young crystalline lens, which tends to be negative, the spherical aberration of the IOL is positive and increases with lens power. Computer simulations and in vitro measurements show that tilts and decentrations might be contributors to the increased third-order aberrations in vivo in comparison with in vitro measurements.

© 2003 Optical Society of America

OCIS Codes
(080.1010) Geometric optics : Aberrations (global)
(080.3620) Geometric optics : Lens system design
(110.3000) Imaging systems : Image quality assessment
(170.1460) Medical optics and biotechnology : Blood gas monitoring
(170.4580) Medical optics and biotechnology : Optical diagnostics for medicine
(330.0330) Vision, color, and visual optics : Vision, color, and visual optics

Sergio Barbero, Susana Marcos, and Ignacio Jiménez-Alfaro, "Optical aberrations of intraocular lenses measured in vivo and in vitro," J. Opt. Soc. Am. A 20, 1841-1851 (2003)

Sort:  Author  |  Year  |  Journal  |  Reset


  1. D. T. Azar, Intraocular Lenses in Cataract and Refractive Surgery (Saunders, Philadelphia, Pa., 2001).
  2. M. J. Simpson, “Optical quality of intraocular lenses,” J. Cataract Refractive Surg. 18, 86–94 (1992).
  3. V. Portney, “Optical testing and inspection methodology for modern intraocular lenses,” J. Cataract Refractive Surg. 18, 607–613 (1992).
  4. N. E. Norrby, L. W. Grossman, E. P. Geraghty, C. F. Kreiner, M. Mihori, A. S. Patel, V. Portney, and D. M. Silberman, “Determining the imaging quality of intraocular lenses,” J. Cataract Refractive Surg. 24, 703–714 (1998).
  5. G. Smith and C. W. Lu, “The spherical aberration of intraocular lenses,” Ophthalmic Physiol. Opt. 8, 287–294 (1988).
  6. D. Atchison, “Third-order aberrations of pseudophakic eyes,” Ophthalmic Physiol. Opt. 9, 205–210 (1989).
  7. D. A. Atchison, “Optical design of intraocular lenses. I. On-axis performance,” Optom. Vision Sci. 66, 492–506 (1989).
  8. D. Atchison, “Design of aspheric intraocular lenses,” Ophthalmic Physiol. Opt. 11, 137–146 (1991).
  9. C. W. Lu and G. Smith, “Aspherizing of intra-ocular lenses,” Ophthalmic Physiol. Opt. 10, 54–66 (1990).
  10. R. Navarro, M. Ferro, P. Artal, and I. Miranda, “Modulation transfer functions of eyes implanted with intraocular lenses,” Appl. Opt. 32, 6359–6367 (1993).
  11. P. Artal, S. Marcos, R. Navarro, I. Miranda, and M. Ferro, “Through focus image quality of eyes implanted with monofocal and multifocal intraocular lenses,” Opt. Eng. 34, 772–779 (1995).
  12. A. Guirao, M. Redondo, E. Geraghty, P. Piers, S. Norrby, and P. Artal, “Corneal optical aberrations and retinal image quality in patients in whom monofocal intraocular lenses were implanted,” Arch. Ophthalmol. 120, 1143–1151 (2002).
  13. J. Santamaria, P. Artal, and J. Bescós, “Determination of the point-spread function of human eyes using a hybrid optical-digital method,” J. Opt. Soc. Am. A 4, 1109–1114 (1987).
  14. P. Mierdel, M. Kaemmerer, H. E. Krinke, and T. Seiler, “Effects of photorefractive keratectomy and cataract surgery on ocular optical erros of higher order,” Graefes Arch. Clin. Exp. Ophthalmol. 237, 725–729 (1999).
  15. M. Mrochen, M. Kaemmerer, P. Mierdel, H. E. Krinke, and T. Seiler, “Principles of Tscherning aberrometry,” J. Refract. Surg. 16, S570–S571 (2000).
  16. K. Hayashi, H. Hayashi, T. Oshika, and F. Hayashi, “Fourier analysis of irregular astigmatism after implantation of 3 types of intraocular lenses,” J. Cataract Refract. Surg. 26, 1510–1516 (2000).
  17. T. Oshika, G. Sugita, T. Tanabe, A. Tomidokoro, and S. Amano, “Regular and irregular astigmatism after superior versus temporal scleral incision cataract surgery,” Ophthalmology 107, 2049–2053 (2000).
  18. R. Gross, “Corneal astigmatism after phacoemulsification and lens implantation through unsutured scleral and corneal tunnel incisions,” Am. J. Ophthalmol. 121, 57–64 (1996).
  19. T. Kohnen, B. Dick, and K. Jacobi, “Comparison of the induced astigmatism after temporal clear corneal tunnel incisions of different sizes,” J. Cataract Refract. Surg. 21, 417–424 (1995).
  20. P. Nielsen, “Prospective evaluation of surgically induced astigmatism and astigmatic keratotomy effects of various self-sealing small incisions,” J. Cataract Refract. Surg. 21, 43–48 (1995).
  21. R. Navarro and M. A. Losada, “Aberrations and relative efficiency of light pencils in the living human eye,” Visual Opt., (1996).
  22. R. Navarro and E. Moreno-Barriuso, “A laser ray-tracing method for optical testing,” Opt. Lett. 24, 951–953 (1999).
  23. S. Barbero, S. Marcos, J. Merayo-Lloves, and E. Moreno-Barriuso, “Validation of the estimation of corneal aberrations from videokeratography in keratoconus,” J. Refract. Surg. 18, 263–270 (2002).
  24. C. Dorronsoro, S. Barbero, L. Llorente, and S. Marcos, “Detailed on-eye measurement of optical performance of rigid gas permeable contact lenses based on ocular and corneal aberrometry,” Optom. Vision Sci. 80, 115–125 (2003).
  25. S. Marcos, S. Barbero, L. Llorente, and J. Merayo-Lloves, “Optical response to myopic LASIK surgery from total and corneal aberration measurements,” Invest. Ophthalmol. Visual Sci. 42, 3349–3356 (2001).
  26. J. McLellan, S. Marcos, and S. A. Burns, “Age-related changes in monochromatic wave aberrations of the human eye,” Invest. Ophthalmol. Visual Sci. 42, 1390–1395 (2001).
  27. A. Guirao, M. Redondo, and P. Artal, “Optical aberrations of the human cornea as a function of age,” J. Opt. Soc. Am. A 17, 1697–1702 (2000).
  28. A. Glasser and M. Campbell, “Presbyopia and the optical changes in the human crystalline lens with age,” Vision Res. 38, 209–229 (1998).
  29. G. Smith, M. J. Cox, R. Calver, and L. F. Garner, “The spherical aberration of the crystalline lens of the human eye,” Vision Res. 41, 235–243 (2001).
  30. E. Moreno-Barriuso, S. Marcos, R. Navarro, and S. Burns, “Comparing laser ray tracing, spatially resolved refractometer and Hartmann-Shack sensor to measure the ocular wave aberration,” Optom. Vision Sci. 78, 152–156 (2001).
  31. R. Navarro and M. A. Losada, “Aberrations and relative efficiency of light pencils in the living human eye,” Optom. Vision Sci. 74, 540–547 (1997).
  32. L. N. Thibos, R. A. Applegate, J. T. Schwiegerling, R. Webb, and V. S. T. Members, “Standards for reporting the optical aberrations of eyes,” in Vision Science and Its Applications, V. Lakshimarayanan, ed., Vol. 35 of OSA Trends in Optics and Photonics Series (Optical Society of America, Washington, D.C., 2000), pp. 110–130.
  33. L. Llorente, L. Diaz-Santana, D. Lara-Saucedo, and S. Marcos, “Aberrations of the human eye in visible and near infrared illumination,” Optom. Vision Sci. 80, 26–35 (2003).
  34. Z-136.1–1993, American National Standards Institute, “American national standard for the safe use of lasers” (The Laser Institute of America, Orlando, Fla., 1993).
  35. S. Barbero, S. Marcos, and J. Merayo-Lloves, “Corneal and total aberrations in a unilateral aphakic patient,” J. Cataract Refract. Surg. 28, 1594–1600 (2002).
  36. A. Guirao and P. Artal, “Corneal wave aberration from videokeratography: accuracy and limitations of the procedure,” J. Opt. Soc. Am. A 17, 955–965 (2000).
  37. M. J. Simpson, “Diffractive multifocal intraocular lens image quality,” Appl. Opt. 31, 3621–3626 (1992).
  38. M. Herzberger, “Colour correction in optical systems and a new dispersion formula,” Opt. Acta 6, 197–215 (1959).
  39. M. Dubbelman, H. A. Weeber, R. G. Van der Heijde, and H. J. Volker-Dieben, “Radius and asphericity of the posterior corneal surface determined by corrected Scheimpflug photography,” Acta Ophthalmol. Scand. 80, 379–383 (2002).
  40. P. Artal, E. Berrio, A. Guirao, and P. Piers, “Contribution of the cornea and internal surfaces to the change of ocular aberrations with age,” J. Opt. Soc. Am. A 19, 137–143 (2002).
  41. P. Waard, J. Jspeert, T. Van de Berg, and P. Jong, “Intraocular light scattering in age-related cataracts,” Invest. Ophthalmol. Visual Sci. 33, 618–625 (1992).
  42. P. Philips, H. Rosskothen, J. Emmanuelli, and C. Koester, “Measurement of intraocular lens decentration and tilt in vivo,” J. Cataract Refract. Surg. 14, 129–135 (1988).
  43. G. Smith and B. K. Pierscionek, “The optical structure of the lens and its contribution to the refractive status of the eye,” Ophthalmic Physiol. Opt. 18, 21–29 (1997).
  44. Y. Matsumoto, T. Hara, K. Chiba, and M. Chikuda, “Optimal incision sites to obtain an astigmatism-free cornea after cataract surgery with a 3.2 mm sutureless incision,” J. Cataract Refract. Surg. 27, 1615–1619 (2001).
  45. F. Mutlu, A. Bilge, H. Altinsoy, and E. Yumusak, “The role of capsulotomy and intraocular lens type on tilt and decentration of polymethylmethacrylate and foldable acrylic lenses,” Ophthalmologica 212, 359–363 (1998).
  46. C. K. Jung, S. K. Chung, and N. H. Baek, “Decentration and tilt: silicone multifocal versus acrylic soft intraocular lenses,” J. Cataract Refract. Surg. 26, 582–585 (2000).
  47. M. Wang, L. Woung, C. Hu, and H. Kuo, “Position of poly(methyl methacrylate) and silicone intraocular lenses after phacoemulsification,” J. Cataract Refract. Surg. 24, 1652–1657 (1998).
  48. A. Glasser and M. Campbell, “Biometric, optical and physical changes in the isolated human crystalline lens with age in relation to presbyopia,” Vision Res. 39, 1991–2015 (1999).
  49. T. Oshika and Y. Shiokawa, “Effect of folding on the optical quality of soft acrylic intraocular lenses,” J. Cataract Refract. Surg. 22, 1360–1364 (1996).

Cited By

Alert me when this paper is cited

OSA is able to provide readers links to articles that cite this paper by participating in CrossRef's Cited-By Linking service. CrossRef includes content from more than 3000 publishers and societies. In addition to listing OSA journal articles that cite this paper, citing articles from other participating publishers will also be listed.

Next Article »

OSA is a member of CrossRef.

CrossCheck Deposited