Adaptive optics-optical coherence tomography: optimizing visualization of microscopic retinal structures in three dimensions
JOSA A, Vol. 24, Issue 5, pp. 1373-1383 (2007)
http://dx.doi.org/10.1364/JOSAA.24.001373
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Abstract
Adaptive optics–optical coherence tomography (AO-OCT) permits improved imaging of microscopic retinal structures by combining the high lateral resolution of AO with the high axial resolution of OCT, resulting in the narrowest three-dimensional (3D) point-spread function (PSF) of all in vivo retinal imaging techniques. Owing to the high volumetric resolution of AO-OCT systems, it is now possible, for the first time, to acquire images of 3D cellular structures in the living retina. Thus, with AO-OCT, those retinal structures that are not visible with AO or OCT alone (e.g., bundles of retinal nerve fiber layers, 3D mosaic of photoreceptors, 3D structure of microvasculature, and detailed structure of retinal disruptions) can be visualized. Our current AO-OCT instrumentation uses spectrometer-based Fourier-domain OCT technology and two-deformable-mirror-based AO wavefront correction. We describe image processing methods that help to remove motion artifacts observed in volumetric data, followed by innovative data visualization techniques [including two-dimensional (2D) and 3D representations]. Finally, examples of microscopic retinal structures that are acquired with the University of California Davis AO-OCT system are presented.
© 2007 Optical Society of America
OCIS Codes
(010.1080) Atmospheric and oceanic optics : Active or adaptive optics
(110.4500) Imaging systems : Optical coherence tomography
(120.3890) Instrumentation, measurement, and metrology : Medical optics instrumentation
(170.0110) Medical optics and biotechnology : Imaging systems
(170.4470) Medical optics and biotechnology : Ophthalmology
(220.1000) Optical design and fabrication : Aberration compensation
ToC Category:
Image Processing
History
Original Manuscript: August 15, 2006
Revised Manuscript: November 13, 2006
Manuscript Accepted: December 18, 2006
Published: April 11, 2007
Virtual Issues
Vol. 2, Iss. 6 Virtual Journal for Biomedical Optics
Citation
Robert J. Zawadzki, Stacey S. Choi, Steven M. Jones, Scot S. Oliver, and John S. Werner, "Adaptive optics-optical coherence tomography: optimizing visualization of microscopic retinal structures in three dimensions," J. Opt. Soc. Am. A 24, 1373-1383 (2007)
http://www.opticsinfobase.org/josaa/abstract.cfm?URI=josaa-24-5-1373
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