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Journal of the Optical Society of America A

Journal of the Optical Society of America A

| OPTICS, IMAGE SCIENCE, AND VISION

  • Editor: Stephen A. Burns
  • Vol. 24, Iss. 5 — May. 1, 2007
  • pp: 1417–1425

Adaptive optics scanning laser ophthalmoscopy for in vivo imaging of lamina cribrosa

Abhiram S. Vilupuru, Nalini V. Rangaswamy, Laura J. Frishman, Earl L. Smith, III, Ronald S. Harwerth, and Austin Roorda  »View Author Affiliations


JOSA A, Vol. 24, Issue 5, pp. 1417-1425 (2007)
http://dx.doi.org/10.1364/JOSAA.24.001417


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Abstract

The lamina cribrosa has been postulated from in vitro studies as an early site of damage in glaucoma. Prior in vivo measures of laminar morphology have been confounded by ocular aberrations. In this study the lamina cribrosa was imaged after correcting for ocular aberrations using the adaptive optics scanning laser ophthalmoscope (AOSLO) in normal and glaucomatous eyes of rhesus monkeys. All measured laminar morphological parameters showed increased magnitudes in glaucomatous eyes relative to fellow control eyes, indicating altered structure. The AOSLO provides high-quality images of the lamina cribrosa and may have potential as a tool for early identification of glaucoma.

© 2007 Optical Society of America

OCIS Codes
(010.1080) Atmospheric and oceanic optics : Active or adaptive optics
(170.4470) Medical optics and biotechnology : Ophthalmology
(170.4580) Medical optics and biotechnology : Optical diagnostics for medicine
(170.4730) Medical optics and biotechnology : Optical pathology
(170.5810) Medical optics and biotechnology : Scanning microscopy

ToC Category:
Clinical Applications of Retinal Imaging

History
Original Manuscript: July 31, 2006
Manuscript Accepted: September 29, 2006
Published: April 11, 2007

Virtual Issues
Vol. 2, Iss. 6 Virtual Journal for Biomedical Optics

Citation
Abhiram S. Vilupuru, Nalini V. Rangaswamy, Laura J. Frishman, Earl L. Smith III, Ronald S. Harwerth, and Austin Roorda, "Adaptive optics scanning laser ophthalmoscopy for in vivo imaging of lamina cribrosa," J. Opt. Soc. Am. A 24, 1417-1425 (2007)
http://www.opticsinfobase.org/josaa/abstract.cfm?URI=josaa-24-5-1417


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