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Journal of the Optical Society of America A

Journal of the Optical Society of America A

| OPTICS, IMAGE SCIENCE, AND VISION

  • Editor: Stephen A. Burns
  • Vol. 26, Iss. 6 — Jun. 1, 2009
  • pp: 1472–1483

Study of turbid media with light: Recovery of mechanical and optical properties from boundary measurement of intensity autocorrelation of light

Hari. M. Varma, A. K. Nandakumaran, and R. M. Vasu  »View Author Affiliations


JOSA A, Vol. 26, Issue 6, pp. 1472-1483 (2009)
http://dx.doi.org/10.1364/JOSAA.26.001472


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Abstract

We discuss the inverse problem associated with the propagation of the field autocorrelation of light through a highly scattering object like tissue. In the first part of the work, we reconstruct the optical absorption coefficient μ a and particle diffusion coefficient D B from simulated measurements which are integrals of a quantity computed from the measured intensity and intensity autocorrelation g 2 ( τ ) at the boundary. In the second part we recover the mean square displacement (MSD) distribution of particles in an inhomogeneous object from the sampled g 2 ( τ ) measured on the boundary. From the MSD, we compute the storage and loss moduli distributions in the object. We have devised computationally easy methods to construct the sensitivity matrices which are used in the iterative reconstruction algorithms for recovering these parameters from the measurements. The results of the reconstruction of μ a , D B , MSD and the viscoelastic parameters, which are presented, show reasonably good position and quantitative accuracy.

© 2009 Optical Society of America

OCIS Codes
(100.3190) Image processing : Inverse problems
(170.3010) Medical optics and biotechnology : Image reconstruction techniques
(170.3660) Medical optics and biotechnology : Light propagation in tissues
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.4580) Medical optics and biotechnology : Optical diagnostics for medicine
(350.5500) Other areas of optics : Propagation

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: November 5, 2008
Revised Manuscript: April 16, 2009
Manuscript Accepted: April 17, 2009
Published: May 28, 2009

Virtual Issues
Vol. 4, Iss. 8 Virtual Journal for Biomedical Optics

Citation
Hari. M. Varma, A. K. Nandakumaran, and R. M. Vasu, "Study of turbid media with light: Recovery of mechanical and optical properties from boundary measurement of intensity autocorrelation of light," J. Opt. Soc. Am. A 26, 1472-1483 (2009)
http://www.opticsinfobase.org/josaa/abstract.cfm?URI=josaa-26-6-1472


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  32. It is assumed that the detector is fast enough to respond to the decay of g2(m,τ). This can pose difficulties in the case where either the source-detector separation and/or the optical properties and MSD are so large that g2(m,τ) decays very fast. For the simulations we did, corresponding to the average properties and size of human breast, boundary correlation decay is slow enough for measurement.

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