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Journal of the Optical Society of America A

Journal of the Optical Society of America A

| OPTICS, IMAGE SCIENCE, AND VISION

  • Editor: Franco Gori
  • Vol. 28, Iss. 7 — Jul. 1, 2011
  • pp: 1513–1523

Fluorescence lifetime optical tomography in weakly scattering media in the presence of highly scattering inclusions

Vadim Y. Soloviev and Simon R. Arridge  »View Author Affiliations


JOSA A, Vol. 28, Issue 7, pp. 1513-1523 (2011)
http://dx.doi.org/10.1364/JOSAA.28.001513


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Abstract

We consider the problem of fluorescence lifetime optical tomographic imaging in a weakly scattering medium in the presence of highly scattering inclusions. We suggest an approximation to the radiative transfer equation, which results from the assumption that the transport coefficient of the scattering media differs by an order of magnitude for weakly and highly scattering regions. The image reconstruction algorithm is based on the variational framework and employs angularly selective intensity measurements. We present numerical simulation of light scattering in a weakly scattering medium that embeds highly scattering objects. Our reconstruction algorithm is verified by recovering optical and fluorescent parameters from numerically simulated datasets.

© 2011 Optical Society of America

OCIS Codes
(170.0170) Medical optics and biotechnology : Medical optics and biotechnology
(170.3010) Medical optics and biotechnology : Image reconstruction techniques
(290.0290) Scattering : Scattering
(290.7050) Scattering : Turbid media

ToC Category:
Scattering

History
Original Manuscript: April 1, 2011
Manuscript Accepted: May 12, 2011
Published: June 29, 2011

Virtual Issues
Vol. 6, Iss. 8 Virtual Journal for Biomedical Optics

Citation
Vadim Y. Soloviev and Simon R. Arridge, "Fluorescence lifetime optical tomography in weakly scattering media in the presence of highly scattering inclusions," J. Opt. Soc. Am. A 28, 1513-1523 (2011)
http://www.opticsinfobase.org/josaa/abstract.cfm?URI=josaa-28-7-1513


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