Patients with central retinal vein occlusion who later develop iris neovascularization show changes in the amplitude, the timing, and the sensitivity of the electroretinogram b wave. We determined the extent to which rod photoreceptor dysfunction contributes to these changes by recording single-flash electroretinograms from both eyes of 52 patients with unilateral central retinal vein occlusion and fitting the leading edges of a waves with a model of rod phototransduction. Eyes with central retinal vein occlusion showed reductions in photoreceptor gain but no changes in photoreceptor amplitude when compared with the fellow eyes. The reductions were larger in eyes that developed iris neovascularization and were predictive of this complication. Photoreceptor gain reductions accounted for only part of the b-wave timing delays and sensitivity loss; the remainder is attributed to functional loss in the inner nuclear layer.
© 1996 Optical Society of America
Original Manuscript: July 17, 1995
Revised Manuscript: September 12, 1995
Manuscript Accepted: September 13, 1995
Published: March 1, 1996
Mary A. Johnson and Donald C. Hood, "Rod photoreceptor transduction is affected in central retinal vein occlusion associated with iris neovascularization," J. Opt. Soc. Am. A 13, 572-576 (1996)