Deborah E. Giaschi, Graham E. Trope, Angela C. Kothe, and X.-Hua Hong, "Loss of sensitivity to motion-defined form in patients with primary open-angle glaucoma and ocular hypertension," J. Opt. Soc. Am. A 13, 707-716 (1996)
During the past few years many researchers have attempted to find a psychophysical test that will identify at an early stage patients at risk for developing glaucoma. We investigated the ability of a test of motion-defined (MD) form recognition to discriminate between patients with primary open-angle glaucoma (POAG) and control subjects and to identify patients with ocular hypertension (OHT) at risk for developing glaucoma. Performance on two MD tests and three tests of static, luminance-defined (LD) form recognition was compared. Speed thresholds for reading MD letters proved to be the most sensitive test of early glaucomatous damage. 80% of POAG and 38% of OHT patients were abnormal on this test. During a 3-year follow-up period, 50% of these OHT patients developed glaucoma. These psychophysical findings support the hypothesis of early motion deficits in glaucoma.
Bruce A. Drum, Matthew Severns, David K. O’Leary, Robert W. Massof, Harry A. Quigley, Michael E. Breton, and Theodore Krupin Appl. Opt. 28(6) 1135-1144 (1989)
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DVA (high contrast) and DVA (low contrast) are decimal visual acuities for solid isolated letters of 96% contrast and 11% contrast, respectively. MD letter acuity is also given as a decimal value.
Table 2
Clinical Data and Test Results for Patients with POAGa
Numbers in boldface indicate test results more than 1.5 SD from the control group mean.
B, levobunolol; D, dipivefrin; C, carbachol; P, pilocarpine; T, timolol. † Indicates medication prescribed but not yet started at time of testing.
A threshold could not be obtained for this patient at a viewing distance of 3 m. A value of 0.90 deg/s (−0.05 log) was arbitrarily assigned.
Table 3
Sensitivity and Specificity of the Psychophysical Tests
Test
Sensitivity (%)
Specificity (%)
Log speed threshold, MD letters
80
95
Log contrast threshold, LD letters
53
95
DVA (MD letters)
53
100
DVA (high contrast)
7
100
DVA (low contrast)
60
95
Acuity ratio (high/low)
40
95
Table 4
Clinical Data and Test Results for Patients with OHTa
Numbers in boldface indicate test results more than 1.5 SD from the control group mean.
B, levobunolol; T, timolol. † Indicates medication prescribed but not yet started at time of testing.
Tables (4)
Table 1
Means and Standard Deviations for the Psychophysical Tests
DVA (high contrast) and DVA (low contrast) are decimal visual acuities for solid isolated letters of 96% contrast and 11% contrast, respectively. MD letter acuity is also given as a decimal value.
Table 2
Clinical Data and Test Results for Patients with POAGa
Numbers in boldface indicate test results more than 1.5 SD from the control group mean.
B, levobunolol; D, dipivefrin; C, carbachol; P, pilocarpine; T, timolol. † Indicates medication prescribed but not yet started at time of testing.
A threshold could not be obtained for this patient at a viewing distance of 3 m. A value of 0.90 deg/s (−0.05 log) was arbitrarily assigned.
Table 3
Sensitivity and Specificity of the Psychophysical Tests
Test
Sensitivity (%)
Specificity (%)
Log speed threshold, MD letters
80
95
Log contrast threshold, LD letters
53
95
DVA (MD letters)
53
100
DVA (high contrast)
7
100
DVA (low contrast)
60
95
Acuity ratio (high/low)
40
95
Table 4
Clinical Data and Test Results for Patients with OHTa
Numbers in boldface indicate test results more than 1.5 SD from the control group mean.
B, levobunolol; T, timolol. † Indicates medication prescribed but not yet started at time of testing.