OSA's Digital Library

Journal of the Optical Society of America A

Journal of the Optical Society of America A

| OPTICS, IMAGE SCIENCE, AND VISION

  • Vol. 17, Iss. 3 — Mar. 1, 2000
  • pp: 589–596

Physiology of L- and M-cone inputs to H1 horizontal cells in the primate retina

Dennis M. Dacey, Lisa C. Diller, Jan Verweij, and David R. Williams  »View Author Affiliations


JOSA A, Vol. 17, Issue 3, pp. 589-596 (2000)
http://dx.doi.org/10.1364/JOSAA.17.000589


View Full Text Article

Enhanced HTML    Acrobat PDF (469 KB)





Browse Journals / Lookup Meetings

Browse by Journal and Year


   


Lookup Conference Papers

Close Browse Journals / Lookup Meetings

Article Tools

Share
Citations

Abstract

In the primate retina, H1 horizontal cells form an electrically coupled network and receive convergent input from long- (L-) and middle- (M-) wavelength-sensitive cones. Using an in vitro preparation of the intact retina to record the light-evoked voltage responses of H1 cells, we systematically varied the L- and M-cone stimulus contrast and measured the relative L- and M-cone input strength for 137 cells across 33 retinas from three Old World species (Macaca nemestrina, M. fascicularis, and Papio anubis). We found that the L- and the M-cone inputs were summed by the H1 cell in proportion to the stimulus cone contrast, which yielded a measure of what we term L- and M-cone contrast gain. The proportion of L-cone contrast gain was highly variable, ranging from 25% to 90% [mean ± standard deviation, (60±14)%]. This variability was accounted for by retinal location within an individual, with the temporal retina showing a consistently higher percentage of L-cone gain, and by large overall variation across individuals, with the mean percentage of L-cone gain ranging from 32% to 80%. We hypothesize that the relative L- and M-cone contrast gain is determined simply by the relative number of L and M cones in the H1 cell’s receptive field and that the variability in L- and M-cone contrast gain reflects a corresponding variability in the mosaic of L and M cones.

© 2000 Optical Society of America

OCIS Codes
(330.0330) Vision, color, and visual optics : Vision, color, and visual optics
(330.1720) Vision, color, and visual optics : Color vision
(330.4270) Vision, color, and visual optics : Vision system neurophysiology
(330.5310) Vision, color, and visual optics : Vision - photoreceptors
(330.5380) Vision, color, and visual optics : Physiology

History
Original Manuscript: July 19, 1999
Revised Manuscript: September 16, 1999
Manuscript Accepted: August 17, 1999
Published: March 1, 2000

Citation
Dennis M. Dacey, Lisa C. Diller, Jan Verweij, and David R. Williams, "Physiology of L- and M-cone inputs to H1 horizontal cells in the primate retina," J. Opt. Soc. Am. A 17, 589-596 (2000)
http://www.opticsinfobase.org/josaa/abstract.cfm?URI=josaa-17-3-589


Sort:  Author  |  Year  |  Journal  |  Reset  

References

  1. V. C. Smith, J. Pokorny, “Spectral sensitivity of the foveal cone photopigments between 400 and 500 nm,” Vision Res. 15, 161–171 (1975). [CrossRef] [PubMed]
  2. W. A. Rushton, H. D. Baker, “Red–green sensitivity in normal vision,” Vision Res. 4, 75–85 (1964). [CrossRef] [PubMed]
  3. G. H. Jacobs, J. F. Deegan, “Spectral sensitivity of macaque monkeys measured with ERG flicker photometry,” Visual Neurosci. 14, 921–928 (1997). [CrossRef]
  4. P. Lennie, J. Pokorny, V. C. Smith, “Luminance,” J. Opt. Soc. Am. A 10, 1283–1293 (1993). [CrossRef] [PubMed]
  5. A. Roorda, D. R. Williams, “The arrangement of the three cone classes in the living human eye,” Nature 397, 520–522 (1999). [CrossRef] [PubMed]
  6. D. H. Brainard, A. Roorda, Y. Yamauchi, J. B. Calderone, A. Metha, M. Neitz, J. Neitz, D. R. Williams, G. H. Jacobs, “Functional consequences of the relative numbers of L and M cones,” J. Opt. Soc. Am. A 17, 607–614 (2000). [CrossRef]
  7. B. B. Lee, P. R. Martin, A. Valberg, “The physiological basis of heterochromatic flicker photometry demonstrated in the ganglion cells of the macaque retina,” J. Physiol. (London) 404, 323–347 (1988).
  8. R. Shapley, “Parallel neural pathways and visual function,” in The Cognitive Neurosciences, M. S. Gazzaniga, E. Bizzi, I. B. Black, C. Blakemore, L. Cosmides, S. M. Kosslyn, J. E. LeDoux, J. A. Movshon, S. Pinker, M. I. Posner, P. Rakic, D. L. Schacter, J. Tooby, E. Tulving, eds. (MIT Press, Cambridge, Mass., 1995).
  9. D. M. Dacey, “Primate retina: cell types, circuits and color opponency,” in Progress in Retinal and Eye Research, N. N. Osborne, G. J. Chader, eds. (Pergamon, Oxford, UK, 1999), Vol. 18, pp. 737–763.
  10. J. Verweij, D. M. Dacey, B. B. Peterson, S. L. Buck, “Sensitivity and dynamics of rod signals in H1 horizontal cells of the macaque monkey retina,” Vision Res. 39, 3662–3672 (1999). [CrossRef]
  11. D. M. Dacey, B. B. Lee, D. K. Stafford, J. Pokorny, V. C. Smith, “Horizontal cells of the primate retina: cone specificity without spectral opponency,” Science 271, 656–659 (1996). [CrossRef] [PubMed]
  12. A. K. Goodchild, T. L. Chan, U. Grünert, “Horizontal cell connections with short-wavelength-sensitive cones in macaque monkey retina,” Visual Neurosci. 13, 833–845 (1996). [CrossRef]
  13. S. S. Deeb, L. C. Diller, D. R. Williams, D. M. Dacey, “Interindividual and topographical variation of L:M cone ratios in monkey retinas,” J. Opt. Soc. Am. A 17, 538–544 (2000). [CrossRef]
  14. W. H. Swanson, T. Ueno, V. C. Smith, J. Pokorny, “Temporal modulation sensitivity and pulse-detection thresholds for chromatic and luminance perturbations,” J. Opt. Soc. Am. A 4, 1992–2005 (1987). [CrossRef] [PubMed]
  15. D. M. Dacey, B. B. Lee, “The blue-ON opponent pathway in primate retina originates from a distinct bistratified ganglion cell type,” Nature 367, 731–735 (1994). [CrossRef] [PubMed]
  16. D. A. Baylor, B. J. Nunn, J. L. Schnapf, “Spectral sensitivity of cones of the monkey Macaca fascicularis,” J. Physiol. (London) 390, 145–160 (1987).
  17. S. M. Dawis, “Polynomial expressions of pigment nomograms,” Vision Res. 21, 1427–1430 (1981). [CrossRef] [PubMed]
  18. T. D. Lamb, “Photoreceptor spectral sensitivities: common shape in the long-wavelength region,” Vision Res. 35, 3083–3091 (1995). [CrossRef] [PubMed]
  19. H. Wässle, B. B. Boycott, J. Röhrenbeck, “Horizontal cells in the monkey retina: cone connections and dendritic network,” Eur. J. Neurosci. 1, 421–435 (1989). [CrossRef] [PubMed]
  20. D. I. Vaney, “Patterns of neuronal coupling in the retina,” in Progress in Retinal and Eye Research, N. N. Osborne, G. J. Chader, eds. (Pergamon, Oxford, UK, 1994), Vol. 13, pp. 301–355.
  21. D. J. Calkins, “Synaptic organization of cone pathways in the primate retina,” in Color Vision: from Genes to Perception, K. R. Gegenfurtner, L. T. Sharpe, eds. (Cambridge U. Press, New York, 1999), pp. 163–180.
  22. D. M. Schneeweis, J. L. Schnapf, “The photovoltage of macaque cone photoreceptors: adaptation, noise, and kinetics,” J. Neurosci. 19, 1203–1216 (1999). [PubMed]
  23. S. A. Hagstrom, J. Neitz, M. Neitz, “Variations in cone populations for red–green color vision examined by analysis of mRNA,” NeuroReport 9, 1963–1967 (1998). [CrossRef] [PubMed]
  24. J. Bowmaker, “Visual pigments and color vision in primates,” in From Pigments to Perception, A. Valberg, B. B. Lee, eds. (Plenum, New York, 1991), pp. 1–10.
  25. J. D. Mollon, J. K. Bowmaker, “The spatial arrangement of cones in the primate fovea,” Nature 360, 677–679 (1992). [CrossRef] [PubMed]
  26. O. S. Packer, D. R. Williams, D. G. Bensinger, “Photopigment transmittance imaging of the primate photoreceptor mosaic,” J. Neurosci. 16, 2251–2260 (1996). [PubMed]
  27. B. B. Lee, “Receptor inputs to primate ganglion cells,” in Color Vision: from Genes to Perception, K. R. Gegenfurtner, L. T. Sharpe, eds. (Cambridge U. Press, New York, 1999), pp. 203–218.
  28. L. C. Diller, J. Verweij, D. R. Williams, D. M. Dacey, “L and M cone inputs to peripheral parasol and midget ganglion cells in primate retina,” Invest. Ophthalmol. Visual Sci. Suppl. 40, S817 (1999).
  29. O. S. Packer, L. C. Diller, B. B. Lee, D. M. Dacey, “Diffuse cone bipolar cells in macaque monkey retina are spatially opponent,” Invest. Ophthalmol. Visual Sci. Suppl. 40, S790 (1999).

Cited By

Alert me when this paper is cited

OSA is able to provide readers links to articles that cite this paper by participating in CrossRef's Cited-By Linking service. CrossRef includes content from more than 3000 publishers and societies. In addition to listing OSA journal articles that cite this paper, citing articles from other participating publishers will also be listed.


« Previous Article  |  Next Article »

OSA is a member of CrossRef.

CrossCheck Deposited