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Journal of the Optical Society of America A

Journal of the Optical Society of America A

| OPTICS, IMAGE SCIENCE, AND VISION

  • Vol. 18, Iss. 12 — Dec. 1, 2001
  • pp: 2945–2956

Primate retina imaging with polarization-sensitive optical coherence tomography

Mathieu G. Ducros, Jason D. Marsack, H. Grady Rylander, III, Sharon L. Thomsen, and Thomas E. Milner  »View Author Affiliations


JOSA A, Vol. 18, Issue 12, pp. 2945-2956 (2001)
http://dx.doi.org/10.1364/JOSAA.18.002945


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Abstract

Polarization-sensitive optical coherence tomography (PSOCT) is applied to determine the depth-resolved polarization state of light backreflected from the eye. The birefringence of the retinal nerve fiber layer (RNFL) was observed and measured from PSOCT images recorded postmortem in a Rhesus monkey. An image-processing algorithm was developed to identify birefringent regions in acquired PSOCT retinal images and automatically determine the thickness of the RNFL. Values of the RNFL thickness determined from histology and PSOCT were compared. PSOCT may provide a new method to determine RNFL thickness and birefringence for glaucoma diagnostics.

© 2001 Optical Society of America

OCIS Codes
(100.0100) Image processing : Image processing
(170.4470) Medical optics and biotechnology : Ophthalmology
(170.4500) Medical optics and biotechnology : Optical coherence tomography
(170.4580) Medical optics and biotechnology : Optical diagnostics for medicine
(260.1440) Physical optics : Birefringence
(260.5430) Physical optics : Polarization

History
Original Manuscript: October 30, 2000
Revised Manuscript: June 13, 2001
Manuscript Accepted: June 13, 2001
Published: December 1, 2001

Citation
Mathieu G. Ducros, Jason D. Marsack, H. Grady Rylander, Sharon L. Thomsen, and Thomas E. Milner, "Primate retina imaging with polarization-sensitive optical coherence tomography," J. Opt. Soc. Am. A 18, 2945-2956 (2001)
http://www.opticsinfobase.org/josaa/abstract.cfm?URI=josaa-18-12-2945


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