Decline of photopic multifocal electroretinogram responses with age is due primarily to preretinal optical factors
JOSA A, Vol. 19, Issue 1, pp. 173-184 (2002)
http://dx.doi.org/10.1364/JOSAA.19.000173
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Abstract
Age-related changes in photopic retinal function were evaluated topographically with the multifocal electroretinogram (mfERG). Thirty-two subjects between the ages of 16 and 69 participated. There was a strong dependence on age for all mfERG response measures that was strongest for the group of central retinal responses (i.e., within 5 deg eccentricity) and approximately equal for responses between 5 and 20 deg. After adjustment for crystalline lens optical density and pupil diameter, significant effects of age were limited to central first-order (i.e., within 5 deg) and second-order response kernels. Simulation studies support an optical basis for the observed age-related changes. It is concluded that mfERG changes between the ages of 20 and 70 are due predominantly to preretinal optical factors.
© 2002 Optical Society of America
[Optical Society of America ]
OCIS Codes
(330.0330) Vision, color, and visual optics : Vision, color, and visual optics
(330.4270) Vision, color, and visual optics : Vision system neurophysiology
(330.4300) Vision, color, and visual optics : Vision system - noninvasive assessment
(330.4460) Vision, color, and visual optics : Ophthalmic optics and devices
(330.5370) Vision, color, and visual optics : Physiological optics
(330.7310) Vision, color, and visual optics : Vision
Citation
Brad Fortune and Chris A. Johnson, "Decline of photopic multifocal electroretinogram responses with age is due primarily to preretinal optical factors," J. Opt. Soc. Am. A 19, 173-184 (2002)
http://www.opticsinfobase.org/josaa/abstract.cfm?URI=josaa-19-1-173
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