We employ a novel interferometer to measure the angular distribution of light backscattered by a turbid medium. Through comparison of the measured data with the predictions of Mie theory, we are able to determine the size of the scatterers comprising the medium with subwavelength precision. As the technique is based on low-coherence interferometry, we are able to examine the evolution of the angular distribution of scattered light as it propagates into the medium. The effects of multiple scattering as a function of penetration depth in the medium are analyzed. We also present various considerations for extending this technique to determining structural information in biological tissues, such as the effects of a distribution of particle sizes and the need to average out speckle contributions.
© 2002 Optical Society of America
Original Manuscript: May 25, 2001
Revised Manuscript: August 2, 2001
Manuscript Accepted: September 26, 2001
Published: April 1, 2002
Adam Wax, Changhuei Yang, Vadim Backman, Maxim Kalashnikov, Ramachandra R. Dasari, and Michael S. Feld, "Determination of particle size by using the angular distribution of backscattered light as measured with low-coherence interferometry," J. Opt. Soc. Am. A 19, 737-744 (2002)