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Journal of the Optical Society of America A

Journal of the Optical Society of America A


  • Vol. 22, Iss. 7 — Jul. 1, 2005
  • pp: 1357–1368

Estimation of kinetic model parameters in fluorescence optical diffusion tomography

Adam B. Milstein, Kevin J. Webb, and Charles A. Bouman  »View Author Affiliations

JOSA A, Vol. 22, Issue 7, pp. 1357-1368 (2005)

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We present a technique for reconstructing the spatially dependent dynamics of a fluorescent contrast agent in turbid media. The dynamic behavior is described by linear and nonlinear parameters of a compartmental model or some other model with a deterministic functional form. The method extends our previous work in fluorescence optical diffusion tomography by parametrically reconstructing the time-dependent fluorescent yield. The reconstruction uses a Bayesian framework and parametric iterative coordinate descent optimization, which is closely related to Gauss–Seidel methods. We demonstrate the method with a simulation study.

© 2005 Optical Society of America

OCIS Codes
(100.3010) Image processing : Image reconstruction techniques
(100.3190) Image processing : Inverse problems
(100.6950) Image processing : Tomographic image processing
(170.3010) Medical optics and biotechnology : Image reconstruction techniques
(170.6280) Medical optics and biotechnology : Spectroscopy, fluorescence and luminescence
(290.3200) Scattering : Inverse scattering
(290.7050) Scattering : Turbid media

Original Manuscript: July 30, 2004
Revised Manuscript: January 21, 2005
Manuscript Accepted: January 21, 2005
Published: July 1, 2005

Adam B. Milstein, Kevin J. Webb, and Charles A. Bouman, "Estimation of kinetic model parameters in fluorescence optical diffusion tomography," J. Opt. Soc. Am. A 22, 1357-1368 (2005)

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