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Journal of the Optical Society of America A

Journal of the Optical Society of America A


  • Editor: Stephen A. Burns
  • Vol. 24, Iss. 5 — May. 1, 2007
  • pp: 1468–1480

Imaging polarimetry in patients with neovascular age-related macular degeneration

Ann E. Elsner, Anke Weber, Michael C. Cheney, Dean A. VanNasdale, and Masahiro Miura  »View Author Affiliations

JOSA A, Vol. 24, Issue 5, pp. 1468-1480 (2007)

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Imaging polarimetry was used to examine different components of neovascular membranes in age-related macular degeneration. Retinal images were acquired with a scanning laser polarimeter. An innovative pseudocolor scale, based on cardinal directions of color, displayed two types of image information: relative phases and magnitudes of birefringence. Membranes had relative phase changes that did not correspond to anatomical structures in reflectance images. Further, membrane borders in depolarized light images had significantly higher contrasts than those in reflectance images. The retinal birefringence in neovascular membranes indicates optical activity consistent with molecular changes rather than merely geometrical changes.

© 2007 Optical Society of America

OCIS Codes
(100.2960) Image processing : Image analysis
(110.3080) Imaging systems : Infrared imaging
(120.5410) Instrumentation, measurement, and metrology : Polarimetry
(170.4470) Medical optics and biotechnology : Ophthalmology
(290.4210) Scattering : Multiple scattering
(330.4300) Vision, color, and visual optics : Vision system - noninvasive assessment

ToC Category:
Clinical Applications of Retinal Imaging

Original Manuscript: September 6, 2006
Revised Manuscript: January 4, 2007
Manuscript Accepted: January 6, 2007
Published: April 11, 2007

Virtual Issues
Vol. 2, Iss. 6 Virtual Journal for Biomedical Optics

Ann E. Elsner, Anke Weber, Michael C. Cheney, Dean A. VanNasdale, and Masahiro Miura, "Imaging polarimetry in patients with neovascular age-related macular degeneration," J. Opt. Soc. Am. A 24, 1468-1480 (2007)

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