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Journal of the Optical Society of America A

Journal of the Optical Society of America A


  • Editor: Stephen A. Burns
  • Vol. 24, Iss. 7 — Jul. 1, 2007
  • pp: 1969–1974

Quantitative spectrophotometry of scattering media via frequency-domain and constant-intensity measurements

John Crowe, David Morris, Malcolm Woolfson, Paul Rodmell, and John Walker  »View Author Affiliations

JOSA A, Vol. 24, Issue 7, pp. 1969-1974 (2007)

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The attenuation of light by scattering and absorbing media is nonlinearly dependent upon the absorption coefficient, since detected light has experienced many different flight times. The frequency response of such a sample to modulated light is also nonlinear. We derive an expression for the attenuation that includes both the absorption coefficient and the modulation frequency. Its form is a power series whose coefficients are the cumulants of the temporal point-spread function (TPSF). Recasting this expression in terms of intensity leads to a similar expression with the cumulants replaced by the moments of the TPSF. A means of exploiting this relationship to produce estimates of the absolute concentration of the absorbing species is suggested.

© 2007 Optical Society of America

OCIS Codes
(170.3660) Medical optics and biotechnology : Light propagation in tissues
(170.5270) Medical optics and biotechnology : Photon density waves
(290.7050) Scattering : Turbid media
(300.1030) Spectroscopy : Absorption

ToC Category:

Original Manuscript: September 1, 2006
Revised Manuscript: February 19, 2007
Manuscript Accepted: February 20, 2007
Published: June 13, 2007

Virtual Issues
Vol. 2, Iss. 8 Virtual Journal for Biomedical Optics

John Crowe, David Morris, Malcolm Woolfson, Paul Rodmell, and John Walker, "Quantitative spectrophotometry of scattering media via frequency-domain and constant-intensity measurements," J. Opt. Soc. Am. A 24, 1969-1974 (2007)

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