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Journal of the Optical Society of America A

Journal of the Optical Society of America A


  • Editor: Stephen A. Burns
  • Vol. 25, Iss. 2 — Feb. 1, 2008
  • pp: 304–311

Monte Carlo model for studying the effects of melanin concentrations on retina light absorption

Ya Guo, Gang Yao, Bo Lei, and Jinglu Tan  »View Author Affiliations

JOSA A, Vol. 25, Issue 2, pp. 304-311 (2008)

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We developed a Monte Carlo model to calculate light absorption in human and mouse retinas. The retina was modeled as a five-layer spherical structure. The effects of melanin concentrations in the retinal pigment epithelium (RPE) and choroid layer were studied. Variations of blood content in choroid were also considered in the simulation. Our simulation results indicated that light absorption in neural retina was at least 20% higher in albino subjects than in pigmented subjects under both photobleaching and dark-adapted conditions. It can be four times higher at optical wavelengths corresponding to minimal hemoglobin absorption. The elevated absorption at neural retina was attributed to the light backscattered from the choroid and sclera layers. This simulation model may provide useful information in studying light-induced retina damage.

© 2008 Optical Society of America

OCIS Codes
(170.0170) Medical optics and biotechnology : Medical optics and biotechnology
(170.3660) Medical optics and biotechnology : Light propagation in tissues
(290.7050) Scattering : Turbid media
(330.7326) Vision, color, and visual optics : Visual optics, modeling

ToC Category:
Medical Optics and Biotechnology

Original Manuscript: July 18, 2007
Revised Manuscript: October 25, 2007
Manuscript Accepted: November 20, 2007
Published: January 10, 2008

Virtual Issues
Vol. 3, Iss. 3 Virtual Journal for Biomedical Optics

Ya Guo, Gang Yao, Bo Lei, and Jinglu Tan, "Monte Carlo model for studying the effects of melanin concentrations on retina light absorption," J. Opt. Soc. Am. A 25, 304-311 (2008)

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