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Journal of the Optical Society of America A

Journal of the Optical Society of America A

| OPTICS, IMAGE SCIENCE, AND VISION

  • Editor: Stephen A. Burns
  • Vol. 26, Iss. 6 — Jun. 1, 2009
  • pp: 1444–1457

Early-photon fluorescence tomography: spatial resolution improvements and noise stability considerations

Frederic Leblond, Hamid Dehghani, Dax Kepshire, and Brian W. Pogue  »View Author Affiliations


JOSA A, Vol. 26, Issue 6, pp. 1444-1457 (2009)
http://dx.doi.org/10.1364/JOSAA.26.001444


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Abstract

In vivo tissue imaging using near-infrared light suffers from low spatial resolution and poor contrast recovery because of highly scattered photon transport. For diffuse optical tomography (DOT) and fluorescence molecular tomography (FMT), the resolution is limited to about 5–10% of the diameter of the tissue being imaged, which puts it in the range of performance seen in nuclear medicine. This paper introduces the mathematical formalism explaining why the resolution of FMT can be significantly improved when using instruments acquiring fast time-domain optical signals. This is achieved through singular-value analysis of the time-gated inverse problem based on weakly diffused photons. Simulations relevant to mouse imaging are presented showing that, in stark contrast to steady-state imaging, early time-gated intensities (within 200 ps or 400 ps ) can in principle be used to resolve small fluorescent targets (radii from 1.5 to 2.5 mm ) separated by less than 1.5 mm .

© 2009 Optical Society of America

OCIS Codes
(170.3010) Medical optics and biotechnology : Image reconstruction techniques
(170.3660) Medical optics and biotechnology : Light propagation in tissues
(170.6920) Medical optics and biotechnology : Time-resolved imaging
(170.6960) Medical optics and biotechnology : Tomography
(260.2510) Physical optics : Fluorescence

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: March 3, 2009
Manuscript Accepted: April 27, 2009
Published: May 27, 2009

Virtual Issues
Vol. 4, Iss. 8 Virtual Journal for Biomedical Optics

Citation
Frederic Leblond, Hamid Dehghani, Dax Kepshire, and Brian W. Pogue, "Early-photon fluorescence tomography: spatial resolution improvements and noise stability considerations," J. Opt. Soc. Am. A 26, 1444-1457 (2009)
http://www.opticsinfobase.org/josaa/abstract.cfm?URI=josaa-26-6-1444

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