## Region-based reconstruction method for fluorescent molecular tomography

JOSA A, Vol. 27, Issue 10, pp. 2327-2336 (2010)

http://dx.doi.org/10.1364/JOSAA.27.002327

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### Abstract

A common difficulty for the traditional methods of fluorescent molecular tomographic (FMT) reconstruction is that only a small amount of measurements can be used to recover the image comprised of a large number of pixels. This difficulty not only leads to expensive computational cost but also likely results in an unstable solution prone to be affected by the noise in the measurement data. In this paper, we propose a region-based method for reducing the unknowns, where the target areas are determined by searching for the nearest neighbor nodes. In this method, the Hessian matrix of the second-order derivatives is incorporated to speed up the optimization process. An iteration strategy of multi-wavelength measurement is introduced to further improve the accuracy of inverse solutions. Simulation results demonstrate that the proposed approach can significantly speed up the reconstruction process and improve the image quality of FMT.

© 2010 Optical Society of America

**OCIS Codes**

(100.3190) Image processing : Inverse problems

(170.3010) Medical optics and biotechnology : Image reconstruction techniques

(170.3880) Medical optics and biotechnology : Medical and biological imaging

(170.6960) Medical optics and biotechnology : Tomography

(260.2510) Physical optics : Fluorescence

**ToC Category:**

Medical Optics and Biotechnology

**History**

Original Manuscript: June 18, 2010

Revised Manuscript: August 23, 2010

Manuscript Accepted: August 24, 2010

Published: September 29, 2010

**Virtual Issues**

Vol. 5, Iss. 14 *Virtual Journal for Biomedical Optics*

**Citation**

Wei Zou, Jiajun Wang, and David Dagan Feng, "Region-based reconstruction method for fluorescent molecular tomography," J. Opt. Soc. Am. A **27**, 2327-2336 (2010)

http://www.opticsinfobase.org/josaa/abstract.cfm?URI=josaa-27-10-2327

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