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Journal of the Optical Society of America A

Journal of the Optical Society of America A


  • Editor: Franco Gori
  • Vol. 27, Iss. 11 — Nov. 1, 2010
  • pp: A37–A47

System design considerations to improve isoplanatism for adaptive optics retinal imaging

Phillip Bedggood and Andrew Metha  »View Author Affiliations

JOSA A, Vol. 27, Issue 11, pp. A37-A47 (2010)

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Adaptive optics (AO) retinal images are limited by anisoplanatism; wavefront shape varies across the field of view such that only a limited area can achieve diffraction-limited image quality at one time. We explored three alternative AO modalities designed to reduce this effect, drawn from work in astronomy. Optical design analysis and computer modeling was undertaken to predict the benefit of each modality for various schematic eyes and various complexities of the imaging system. Off-axis performance was found to be limited by system parameters and not by the eye itself, due to the inherent off-axis characteristics of the eye’s gradient index lens. This rendered the alternative AO modalities ineffectual compared with conventional AO but did suggest several methods by which anisoplanatism may be reduced by altering the design of conventional AO systems. Several of these design possibilities were explored with further modeling. The best-performing method involved the replacement of system lenses with gradient index versions inspired by the human eye lens. Mirror-based relay optics also demonstrated good off-axis performance, but their advantage was lost in regions of the system suffering from uncorrected higher-order aberration. Incorporating “off-the-plane” beam deviations ameliorated this loss substantially. In this work we also show, to our knowledge for the first time, that the ideal location of a single AO corrector need not lie in the pupil plane.

© 2010 Optical Society of America

OCIS Codes
(010.1080) Atmospheric and oceanic optics : Active or adaptive optics
(110.2760) Imaging systems : Gradient-index lenses
(170.4460) Medical optics and biotechnology : Ophthalmic optics and devices
(080.4035) Geometric optics : Mirror system design

Original Manuscript: January 19, 2010
Revised Manuscript: June 4, 2010
Manuscript Accepted: June 13, 2010
Published: July 20, 2010

Virtual Issues
Vol. 6, Iss. 1 Virtual Journal for Biomedical Optics

Phillip Bedggood and Andrew Metha, "System design considerations to improve isoplanatism for adaptive optics retinal imaging," J. Opt. Soc. Am. A 27, A37-A47 (2010)

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  1. H. W. Babcock, “The possibility of compensating astronomical seeing,” Publ. Astron. Soc. Pac. 65, 229–236 (1953). [CrossRef]
  2. J. Liang, D. R. Williams, and D. T. Miller, “Supernormal vision and high-resolution retinal imaging through adaptive optics,” J. Opt. Soc. Am. A 14, 2884–2892 (1997). [CrossRef]
  3. D. L. Fried, “Anisoplanatism in adaptive optics,” J. Opt. Soc. Am. A 72, 52–61 (1982). [CrossRef]
  4. P. A. Bedggood, R. Ashman, G. Smith, and A. B. Metha, “Multiconjugate adaptive optics applied to an anatomically accurate human eye model,” Opt. Express 14, 8019–8030 (2006). [CrossRef] [PubMed]
  5. E. M. Maida, K. Venkateswaran, J. Marsack, and A. Roorda, “What is the size of the isoplanatic patch in the human eye?” (http://wwwcfao.ucolick.org/EO//internshipsnew/mainland/posters/erika.pdf, 2004).
  6. J. Tarrant and A. Roorda, “The extent of the isoplanatic patch of the human eye,” (http://vision.berkeley.edu/wildsoet/Arvo2006/Isoplanatic%20Patch_Janice_Austin.pdf, 2006).
  7. D. A. Atchison, S. D. Lucas, R. Ashman, M. A. Huynh, D. W. Schilt, and P. Q. Ngo, “Refraction and aberration across the horizontal central 10 degrees of the visual field,” Optom. Vision Sci. 83, 213–221 (2006). [CrossRef]
  8. A. Dubinin, T. Cherezova, A. Belyakov, and A. Kudryashov, “Anisoplanatism in human retina imaging,” Proc. SPIE 5894, 88–94 (2005).
  9. A. Dubinin, T. Cherezova, A. Belyakov, and A. Kudryashov, “Human eye anisoplanatism: eye as a lamellar structure,” Proc. SPIE 6138, 260–266 (2006).
  10. P. A. Bedggood, M. Daaboul, R. Ashman, G. Smith, and A. Metha, “Characteristics of the human isoplanatic patch and implications for adaptive optics retinal imaging,” J. Biomed. Opt. 13, 024008 (2008). [CrossRef] [PubMed]
  11. R. H. Dicke, “Phase-contrast detection of telescope seeing errors and their correction,” Astrophys. J. 198, 605–615 (1975). [CrossRef]
  12. J. M. Beckers, “Increasing the size of the isoplanatic patch with multiconjugate adaptive optics,” in Proceedings of ESO Conference on Very Large Telescopes and Their Instrumentation (European Southern Observatory, 1988), 693–703.
  13. D. C. Johnston and B. M. Welsh, “Analysis of multiconjugate adaptive optics,” J. Opt. Soc. Am. A 11, 394–408 (1994). [CrossRef]
  14. M. Tallon and R. Foy, “Adaptive telescope with laser probe: isoplanatism and cone effect,” Astron. Astrophys. 235, 549–557 (1990).
  15. J. Thaung, P. Knutsson, Z. Popovic, and M. Owner-Petersen, “Dual-conjugate adaptive optics for wide-field high-resolution retinal imaging,” Opt. Express 17, 4454–4467 (2009). [CrossRef] [PubMed]
  16. A. Tokovinin, “Seeing improvement with ground-layer adaptive optics,” Publ. Astron. Soc. Pac. 116, 941–951 (2004). [CrossRef]
  17. P. Artal and A. Guirao, “Contributions of the cornea and the lens to the aberrations of the human eye,” Opt. Lett. 23, 1713–1715 (1998). [CrossRef]
  18. P. Artal, A. Guirao, E. Berrio, and D. R. Williams, “Compensation of corneal aberrations by the internal optics in the human eye,” J. Vision 1, 1–8 (2001). [CrossRef]
  19. G. Smith and D. A. Atchison, “The gradient index and spherical aberration of the lens of the human eye,” Appl. Opt. 21, 317–326 (2001).
  20. G. Smith, P. Bedggood, R. Ashman, M. Daaboul, and A. Metha, “Exploring ocular aberrations with a schematic human eye model,” Optom. Vision Sci. 85, 330–340 (2008). [CrossRef]
  21. A. Roorda, F. Romero-Borja, W. Donnelly Iii, H. Queener, T. Hebert, and M. Campbell, “Adaptive optics scanning laser ophthalmoscopy,” Opt. Express 10, 405–412 (2002). [PubMed]
  22. R. Navarro, J. Santamaría, and J. Bescós, “Accommodation-dependent model of the human eye with aspherics,” J. Opt. Soc. Am. A 2, 1273–1281 (1985). [CrossRef] [PubMed]
  23. H.-L. Liou and N. A. Brennan, “Anatomically accurate, finite model eye for optical modelling,” J. Opt. Soc. Am. A 14, 1684–1694 (1997). [CrossRef]
  24. A. V. Goncharov and C. Dainty, “Wide-field schematic eye models with gradient-index lens,” J. Opt. Soc. Am. A 24, 2157–2174 (2007). [CrossRef]
  25. I. Escudero-Sanz and R. Navarro, “Off-axis aberrations of a wide-angle schematic eye model,” J. Opt. Soc. Am. A 16, 1881–1891 (1999). [CrossRef]
  26. M. Born and E. Wolf, Principles of Optics, 5th ed. (Pergamon, 1975).
  27. A. V. Goncharov, J. C. Dainty, S. Esposito, and A. Puglisi, “Laboratory MCAO test-bed for developing wavefront sensing concepts,” Opt. Express 13, 5580–5590 (2005). [CrossRef] [PubMed]
  28. B. L. Ellerbroek, “Efficient computation of minimum-variance wave-front reconstructors with sparse matrix techniques,” J. Opt. Soc. Am. A 19, 1803–1816 (2002). [CrossRef]
  29. A. Gómez-Vieyra, A. Dubra, D. Malacara-Hernández, and D. R. Williams, “First-order design of off-axis reflective ophthalmic adaptive optics systems using afocal telescopes,” Opt. Express 17, 18906–18919 (2009). [CrossRef]
  30. S. A. Burns, R. Tumbar, A. E. Elsner, D. Ferguson, and D. X. Hammer, “Large-field-of-view, modular, stabilized, adaptive-optics-based scanning laser ophthalmoscope,” J. Opt. Soc. Am. A 24, 1313–1326 (2007). [CrossRef]
  31. J. Porter, A. Guirao, I. G. Cox, and D. R. Williams, “Monochromatic aberrations of the human eye in a large population,” J. Opt. Soc. Am. A 18, 1793–1803 (2001). [CrossRef]
  32. H. Cheng, J. K. Barnett, A. S. Vilupuru, J. D. Marsack, S. Kasthurirangan, R. A. Applegate, and A. Roorda, “A population study on changes in wave aberrations with accommodation,” J. Vision 4, 272–280 (2004). [CrossRef]
  33. G. Smith and D. Atchison, The Eye and Visual Optical Instruments (Cambridge Univ. Press, 1997). [CrossRef]
  34. L. N. Thibos, R. A. Applegate, J. T. Schwiegerling, and R. Webb, “Standards for reporting the optical aberrations of eyes,” J. Refract. Surg. 18, S652–S660 (2002). [PubMed]
  35. P. Bedggood, “Adaptive optics methods to increase the isoplanatic patch size for human retinal imaging,” Ph.D. dissertation (University of Melbourne, 2008).
  36. L. N. Thibos, X. Hong, A. Bradley, and X. Cheng, “Statistical variation of aberration structure and image quality in a normal population of healthy eyes,” J. Opt. Soc. Am. A 19, 2329–2348 (2002). [CrossRef]

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