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Journal of the Optical Society of America A

Journal of the Optical Society of America A


  • Editor: Franco Gori
  • Vol. 29, Iss. 6 — Jun. 1, 2012
  • pp: 980–988

Tomographic imaging with polarized light

Vadim Y. Soloviev, Giannis Zacharakis, George Spiliopoulos, Rosy Favicchio, Teresa Correia, Simon R. Arridge, and Jorge Ripoll  »View Author Affiliations

JOSA A, Vol. 29, Issue 6, pp. 980-988 (2012)

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We report three-dimensional tomographic reconstruction of optical parameters for the mesoscopic light scattering regime from experimentally obtained datasets by using polarized light. We present a numerically inexpensive approximation to the radiative transfer equation governing the polarized light transport. This approximation is employed in the reconstruction algorithm, which computes two optical parameters by using parallel and perpendicular polarizations of transmitted light. Datasets were obtained by imaging a scattering phantom embedding highly absorbing inclusions. Reconstruction results are presented and discussed.

© 2012 Optical Society of America

OCIS Codes
(170.0170) Medical optics and biotechnology : Medical optics and biotechnology
(170.3010) Medical optics and biotechnology : Image reconstruction techniques
(290.0290) Scattering : Scattering
(290.7050) Scattering : Turbid media

ToC Category:

Original Manuscript: November 22, 2011
Revised Manuscript: February 28, 2012
Manuscript Accepted: March 5, 2012
Published: May 23, 2012

Virtual Issues
Vol. 7, Iss. 8 Virtual Journal for Biomedical Optics

Vadim Y. Soloviev, Giannis Zacharakis, George Spiliopoulos, Rosy Favicchio, Teresa Correia, Simon R. Arridge, and Jorge Ripoll, "Tomographic imaging with polarized light," J. Opt. Soc. Am. A 29, 980-988 (2012)

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  1. P. J. Shaw, D. A. Agard, Y. Hiraoko, and J. W. Sedat, “Tilted view reconstruction in optical microscopy, three-dimensional reconstruction of Drosophila melanogaster embryo nuclei,” Biophys. J. 55, 101–110 (1989). [CrossRef]
  2. C. S. Brown, D. H. Burns, F. A. Spelman, and A. C. Nelson, “Computed tomography from optical projections for three-dimensional reconstruction of thick objects,” Appl. Opt. 31, 6247–6254 (1992). [CrossRef]
  3. J. Sharpe, U. Ahlgren, P. Perry, B. Hill, A. Ross, J. Hecksher-Sorensen, R. Baldock, and D. Davidson, “Optical projection tomography as a tool for 3D microscopy and gene expression studies,” Science 296, 541–545 (2002). [CrossRef]
  4. J. Sharpe, “Optical projection tomography as a new tool for studying embryo anatomy,” J. Anatomy 202, 175–181 (2003). [CrossRef]
  5. M. Fauver, E. J. Seibel, J. R. Rahn, M. G. Meyer, F. W. Patten, T. Neumann, and A. C. Nelson, “Three-dimensional imaging of single isolated cell nuclei using optical projection tomography,” Opt. Express 13, 4210–4223 (2005). [CrossRef]
  6. C. Vinegoni, C. Pitsouli, D. Razansky, N. Perrimon, and V. Ntziachristos, “Live imaging of drosophila melanogaster pupae with mesoscopic fluorescence tomography,” Nat. Methods 5, 45–47 (2007). [CrossRef]
  7. H. Meyer, A. Darrell, A. Metaxakis, C. Savakis, and J. Ripoll, “Optical projection tomography for in-vivo imaging of drosophila melanogaster,” Microsc. Anal. 22, 19–21 (2008).
  8. J. McGinty, H. B. Taylor, L. Chen, L. Bugeon, J. R. Lamb, M. J. Dallman, and P. M. W. French, “In vivo fluorescence lifetime optical projection tomography,” Biomed. Opt. Express 2, 1340–1350 (2011). [CrossRef]
  9. U. J. Birk, A. Darrell, N. Konstantinides, A. Sarasa-Renedo, and J. Ripoll, “Improved reconstructions and generalized filtered back projection for optical projection tomography,” Appl. Opt. 50, 392–398 (2011). [CrossRef]
  10. M. Rieckher, U. J. Birk, H. Meyer, J. Ripoll, and N. Tavernarakis, “Microscopic optical projection tomography in vivo,” PLoS ONE 6, e18963 (2011).
  11. M. Oldham, H. Sakhalkar, T. Oliver, Y. M. Wang, J. P. Kirpatrick, Y. Cao, C. Badea, G. A. Johnson, and M. Dewhirst, “Three-dimensional imaging of xenograft tumors using optical computed and emission tomography,” Med. Phys. 33, 3193–3202 (2006). [CrossRef]
  12. A. E. Papadakis, G. Zacharakis, T. G. Maris, J. Ripoll, and John Damilakis, “A new optical-CT apparatus for 3-D radiotherapy dosimetry: is free space scanning feasible?” IEEE Trans. Med. Imaging 29, 1204–1212 (2010). [CrossRef]
  13. A. E. Papadakis, T. G. Maris, G. Zacharakis, V. Papoutsaki, C. Varveris, J. Ripoll, and J. Damilakis, “Technical note: afast laser-based optical-CT scanner for three-dimensional radiation dosimetry,” Med. Phys. 38, 830–835 (2011). [CrossRef]
  14. X. Wang and L. V. Wang, “Propagation of polarized light in birefringent turbid media: a Monte Carlo study,” J. Biomed. Opt. 7, 279–290 (2002). [CrossRef]
  15. S. Chandrasekhar, Radiative Transfer (Dover, 1960).
  16. V. V. Sobolev, A Treatise on Radiative Transfer (D. Van Nostrand, 1963).
  17. V. Y. Soloviev and S. R. Arridge, “Optical tomography in weakly scattering media in the presence of highly scattering inclusions,” Biomed. Opt. Express 2, 440–451 (2011). [CrossRef]
  18. V. Y. Soloviev and S. R. Arridge, “Fluorescence lifetime optical tomography in weakly scattering media in the presence of highly scattering inclusions,” J. Opt. Soc. Am. A 28, 1513–1523(2011). [CrossRef]
  19. V. Y. Soloviev, A. Bassi, L. Fieramonti, G. Valentini, C. D’ Andrea, and S. R. Arridge, “Angularly selective mesoscopic tomography,” Phys. Rev. E 84, 051915 (2011). [CrossRef]
  20. R. L. Siddon, “Fast calculation of the exact radiological path for a three-dimensional CT array,” Med. Phys. 12, 252–255 (1985). [CrossRef]
  21. N. Ghosh, M. F. G. Wood, and I. A. Vitkin, “Mueller matrix decomposition for extraction of individual polarization parameters from complex turbid media exhibiting multiple scattering, optical activity, and linear birefringence,” J. Biomed. Opt. 13, 044036 (2008). [CrossRef]
  22. M. Ahmad, S. Alali, A. Kim, M. F. G. Wood, M. Ikram, and I. Alex Vitkin, “Do different turbid media with matched bulk optical properties also exhibit similar polarization properties?,” Biomed. Opt. Express 2, 3248–3258 (2011). [CrossRef]
  23. S. R. Deans, The Radon Transform and Some of Its Applications (Dover, 2007).
  24. H. C. van de Hulst, Light Scattering by Small Particles (Dover, 1981).
  25. S. R. Arridge, “Optical tomography in medical imaging,” Inverse Probl. 15, R41–R93 (1999). [CrossRef]
  26. S. R. Arridge and J. Schotland, “Optical tomography: forward and inverse problems,” Inverse Probl. 25, 123010 (2009). [CrossRef]
  27. V. Y. Soloviev, C. D’Andrea, P. S. Mohan, G. Valentini, R. Cubeddu, and S. R. Arridge, “Fluorescence lifetime optical tomography with discontinuous Galerkin discretisation scheme,” Biomed. Opt. Express 1, 998–1013 (2010). [CrossRef]

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