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Journal of the Optical Society of America A

Journal of the Optical Society of America A


  • Editor: Franco Gori
  • Vol. 30, Iss. 8 — Aug. 1, 2013
  • pp: 1613–1619

Methodology to optimize detector geometry in fluorescence tomography of tissue using the minimized curvature of the summed diffuse sensitivity projections

Robert W. Holt, Frederic L. Leblond, and Brian W. Pogue  »View Author Affiliations

JOSA A, Vol. 30, Issue 8, pp. 1613-1619 (2013)

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The dependence of the sensitivity function in fluorescence tomography on the geometry of the excitation source and detection locations can severely influence an imaging system’s ability to recover fluorescent distributions. Here a methodology for choosing imaging configuration based on the uniformity of the sensitivity function is presented. The uniformity of detection sensitivity is correlated with reconstruction accuracy in silico, and reconstructions in a murine head model show that a detector configuration optimized using Nelder–Mead minimization improves recovery over uniformly sampled tomography.

© 2013 Optical Society of America

OCIS Codes
(120.4570) Instrumentation, measurement, and metrology : Optical design of instruments
(170.0110) Medical optics and biotechnology : Imaging systems
(170.6960) Medical optics and biotechnology : Tomography

ToC Category:
Imaging Systems

Original Manuscript: April 25, 2013
Revised Manuscript: June 26, 2013
Manuscript Accepted: June 27, 2013
Published: July 19, 2013

Virtual Issues
Vol. 8, Iss. 9 Virtual Journal for Biomedical Optics

Robert W. Holt, Frederic L. Leblond, and Brian W. Pogue, "Methodology to optimize detector geometry in fluorescence tomography of tissue using the minimized curvature of the summed diffuse sensitivity projections," J. Opt. Soc. Am. A 30, 1613-1619 (2013)

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