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Journal of the Optical Society of America A

Journal of the Optical Society of America A


  • Vol. 5, Iss. 4 — Apr. 1, 1988
  • pp: 593–597

Variability in responses of retinal ganglion cells

Michael W. Levine, Roger P. Zimmerman, and Violeta Carrion-Carire  »View Author Affiliations

JOSA A, Vol. 5, Issue 4, pp. 593-597 (1988)

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Changes in the maintained discharge of retinal ganglion cells have been modeled by addition of noise to a rate-setting signal, whereas the responses of cortical cells have been reported to indicate a nonlinear relationship between noise and signal. To determine whether this represents a difference between retinal cells and cortical cells, the variance of light-evoked responses of ganglion cells in the retinas of goldfish was compared with the magnitude of the responses. Variance increased for higher firing rates. These results are discussed in terms of mechanisms by which light-evoked signals might interact with the variability of maintained discharges.

© 1988 Optical Society of America

Original Manuscript: March 25, 1987
Manuscript Accepted: October 14, 1987
Published: April 1, 1988

Michael W. Levine, Roger P. Zimmerman, and Violeta Carrion-Carire, "Variability in responses of retinal ganglion cells," J. Opt. Soc. Am. A 5, 593-597 (1988)

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  1. M. W. Levine, “Variability in the maintained discharges of retinal ganglion cells,” J. Opt. Soc. Am. A 4, 2308–2320 (1987). [CrossRef]
  2. J. G. Robson, J. B. Troy, “The nature of the noise in cat retinal ganglion cells,” J. Opt. Soc. Am. A 4, 2301–2307 (1987). [CrossRef] [PubMed]
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  4. D. J. Tolhurst, “Sources of noise in cortical neurons,” submitted to J. Opt. Soc. Am. A.
  5. M. W. Levine, J. M. Shefner, “Variability in ganglion cell firing patterns: implications for separate ‘on’ and ‘off’ processes,” Vision Res. 17, 765–776 (1977). [CrossRef]
  6. J. M. Shefner, M. W. Levine, “A comparison of properties of goldfish retinal ganglion cells as a function of lighting conditions during dissection,” Vision Res. 19, 83–89 (1979). [CrossRef] [PubMed]
  7. K. S. Ginsburg, J. A. Johnsen, M. W. Levine, “Common noise in the firing of neighbouring ganglion cells in goldfish retina,” J. Physiol. 351, 433–450 (1984). [PubMed]
  8. J. M. Shefner, M. W. Levine, “An analysis of receptor inputs to and spatial distribution of ganglion cell on and off processes,” Vision Res. 19, 647–653 (1979). [CrossRef] [PubMed]
  9. M. W. Levine, J. M. Shefner, “X-like and not X-like cells in goldfish retina,” Vision Res. 19, 95–97 (1979). [CrossRef] [PubMed]
  10. B. W. van Dijk, J. L. Ringo, “The variation in the light responses of carp retinal ganglion cells is independent of response amplitude,” Vision Res. 27, 493–497 (1987). [CrossRef] [PubMed]
  11. H. B. Barlow, W. R. Levick, M. Yoon, “Responses to single quanta of light in retinal ganglion cells of the cat,” Vision Res. Suppl. 3, 87–101 (1971). [CrossRef]
  12. B. E. A. Saleh, M. C. Teich, “Multiplication and refractoriness in the cat’s retinal-ganglion-cell discharge at low light levels,” Biol. Cybern. 52, 101–107 (1985). [CrossRef]
  13. M. W. Levine, J. M. Shefner, “The effects of photic stimulation upon the variability of the interspike intervals in goldfish ganglion cells,” Vision Res. 17, 793–797 (1977). [CrossRef] [PubMed]
  14. M. W. Levine, J. M. Shefner, “A model for the variability of interspike intervals during sustained firing of a retinal neuron,” Biophys J. 19, 241–252 (1977). [CrossRef] [PubMed]
  15. G. Gestri, “Pulse frequency modulation in neural systems. A random model,” Biophys. J. 11, 98–109 (1971). [CrossRef] [PubMed]
  16. M. W. Levine, J. M. Shefner, “Independence of ‘on’ and ‘off’ responses of retinal ganglion cells,” Science 190, 1215–1217 (1975). [CrossRef] [PubMed]

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