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Journal of the Optical Society of America B

Journal of the Optical Society of America B


  • Vol. 22, Iss. 5 — May. 1, 2005
  • pp: 1024–1036

Laser-induced photothermoacoustic pressure-wave pulses in a polystyrene well and water system used for photomechanical drug delivery

Andreas Mandelis, Natalie Baddour, Ying Cai, and Richard G. Walmsley  »View Author Affiliations

JOSA B, Vol. 22, Issue 5, pp. 1024-1036 (2005)

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A linear time-domain thermoelastic (photothermoacoustic) theory of a composite solid–liquid geometry has been developed. The theory includes multiple interreflections at all interfaces, acoustic diffraction and viscosity effects, and natural mixed, rigid, and free boundary conditions at the solid surface where laser-pulse incidence occurs (air–polystyrene interface). The theory was applied to experimental pressure-wave pulses from a Nd:YAG laser in a polystyrene well target and water system used for photomechanical drug delivery studies. Good fits of the linear theory to tripolar experimental pressure waveforms were possible at laser-pulse irradiances 100 MW cm 2 , especially at distances 5 mm from the solid–fluid interface. It was further determined from the combined theoretical and experimental approach that the onset of significant hydrodynamic nonlinearity in the water appears for laser-pulse irradiances in the 165 - MW cm 2 range, especially at axial distances z 8 mm , as expected theoretically from the laser-ablation-induced nonlinearity of stress-wave propagation in the solid–water system.

© 2005 Optical Society of America

OCIS Codes
(170.7170) Medical optics and biotechnology : Ultrasound
(170.7180) Medical optics and biotechnology : Ultrasound diagnostics

Andreas Mandelis, Natalie Baddour, Ying Cai, and Richard G. Walmsley, "Laser-induced photothermoacoustic pressure-wave pulses in a polystyrene well and water system used for photomechanical drug delivery," J. Opt. Soc. Am. B 22, 1024-1036 (2005)

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