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Journal of the Optical Society of America B

Journal of the Optical Society of America B

| OPTICAL PHYSICS

  • Editor: Henry Van Driel
  • Vol. 26, Iss. 11 — Nov. 1, 2009
  • pp: 2161–2166

Maximization of nonlinear fluorescence from ultrasmall ( 2 nm ) semiconductor quantum dots to be used for deep tissue imaging

L. Wang and R. K. Jain  »View Author Affiliations


JOSA B, Vol. 26, Issue 11, pp. 2161-2166 (2009)
http://dx.doi.org/10.1364/JOSAB.26.002161


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Abstract

We propose the use of ultrasmall semiconductor quantum dots (USQDs) for specialized bio-imaging applications, and discuss methods for enhancing fluorescent signals from USQDs to be used for two-photon-absorption based deep tissue imaging. In particular, we report optimizing the excitation wavelength for two-photon absorption-induced fluorescence (TPAF) in Cd Se Zn S SQDs and demonstrate a 68-fold enhancement in the fluorescence signal when the TPAF excitation wavelength is changed from 900 nm to 780 nm .

© 2009 Optical Society of America

OCIS Codes
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(190.0190) Nonlinear optics : Nonlinear optics

ToC Category:
Nonlinear Optics

History
Original Manuscript: March 11, 2009
Revised Manuscript: June 16, 2009
Manuscript Accepted: June 20, 2009
Published: October 27, 2009

Virtual Issues
Vol. 4, Iss. 13 Virtual Journal for Biomedical Optics

Citation
L. Wang and R. K. Jain, "Maximization of nonlinear fluorescence from ultrasmall (≤2 nm) semiconductor quantum dots to be used for deep tissue imaging," J. Opt. Soc. Am. B 26, 2161-2166 (2009)
http://www.opticsinfobase.org/josab/abstract.cfm?URI=josab-26-11-2161

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