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Journal of the Optical Society of Korea

Journal of the Optical Society of Korea


  • Vol. 13, Iss. 1 — Mar. 25, 2009
  • pp: 166–170

Hemodynamic Responses of Rat Brain Measured by Near-infrared Spectroscopy During Various Whisker Stimulations

Seung-Duk Lee, Dalk-Won Koh, Ki-Woon Kwon, Hyun-Joo Lee, Yiran Lang, Hyung-Cheul Shin, and Beop-Min Kim  »View Author Affiliations

Journal of the Optical Society of Korea, Vol. 13, Issue 1, pp. 166-170 (2009)

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NIRS (Near-infrared spectroscopy) is a relatively, new, non-invasive, and non-ionizing method of measuring hemodynamic responses in thick biological tissues such as the cerebral cortex. In this study, we measured the hemodynamic responses of the rat barrel cortex to whisker stimulation by using a frequency-domain NIRS system. We designed multiple optical probes comprising multi-mode optical fibers and manipulating arms, both of which can be easily applied to small animals. Various electrical stimulations were applied to rat whiskers at different voltage levels and stimulation frequencies. Our results show that the hemodynamic responses are highly dependent on the stimulation voltage level, and not so much on stimulation frequency. This paper suggests that NIRS technology is highly suitable for the study of small animal brains.

© 2009 Optical Society of Korea

OCIS Codes
(170.1470) Medical optics and biotechnology : Blood or tissue constituent monitoring
(170.3660) Medical optics and biotechnology : Light propagation in tissues
(170.3880) Medical optics and biotechnology : Medical and biological imaging

Original Manuscript: August 25, 2008
Revised Manuscript: October 10, 2008
Manuscript Accepted: December 19, 2008
Published: March 25, 2009

Seung-Duk Lee, Dalk-Won Koh, Ki-Woon Kwon, Hyun-Joo Lee, Yiran Lang, Hyung-Cheul Shin, and Beop-Min Kim, "Hemodynamic Responses of Rat Brain Measured by Near-infrared Spectroscopy During Various Whisker Stimulations," J. Opt. Soc. Korea 13, 166-170 (2009)

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