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Journal of the Optical Society of Korea

Journal of the Optical Society of Korea


  • Vol. 10, Iss. 1 — Mar. 25, 2006
  • pp: 42–47

Murine Heart Wall Imaging with Optical Coherence Tomography

Jee-Hyun Kim and Byeong-Ha Lee  »View Author Affiliations

Journal of the Optical Society of Korea, Vol. 10, Issue 1, pp. 42-47 (2006)

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M-mode imaging of the in vivo murine myocardium using optical coherence tomography (OCT) is described. Application of conventional techniques (e.g. MRI, Ultrasound imaging) for imaging the murine myocardium is problematic because the wall thickness is less than 1.5 mm (20 g mouse), and the heart rate can be as high as six hundred beats per minute. To acquire a real-time image of the murine myocardium, OCT can provide sufficient spatial resolution (<TEX>$10{\mu}m$</TEX>) and imaging speed (1000 A-scans/s). Strong light scattering by blood in the heart causes significant light attenuation, which makes delineation of the endocardium-chamber boundary problematic. To measure the thickness change of the myocardium during one heart beat cycle, a myocardium edge detection algorithm is developed and demonstrated.

© 2006 Optical Society of Korea

OCIS Codes
(110.4500) Imaging systems : Optical coherence tomography
(120.3890) Instrumentation, measurement, and metrology : Medical optics instrumentation
(170.0170) Medical optics and biotechnology : Medical optics and biotechnology

Original Manuscript: February 7, 2006
Revised Manuscript: February 7, 2006
Published: March 1, 2006

Jee-Hyun Kim and Byeong-Ha Lee, "Murine Heart Wall Imaging with Optical Coherence Tomography," J. Opt. Soc. Korea 10, 42-47 (2006)

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