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Journal of the Optical Society of Korea

Journal of the Optical Society of Korea

| PUBLISHED BY THE OPTICAL SOCIETY OF KOREA

  • Vol. 10, Iss. 3 — Sep. 25, 2006
  • pp: 99–104

Nanoparticle Contrast in Magneto-Motive Optical Doppler Tomography

Jee-Hyun Kim and Jung-Hwan Oh  »View Author Affiliations


Journal of the Optical Society of Korea, Vol. 10, Issue 3, pp. 99-104 (2006)


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Abstract

We introduce a novel contrast mechanism for imaging superparamagnetic iron oxide (SPIO) nanoparticles (average diameter <TEX>${\sim}100nm$</TEX>) using magneto-motive optical Doppler tomography (MM-ODT), which combines an externally applied temporally oscillating high-strength magnetic field with ODT to detect the nanoparticles flowing through a glass capillary tube. A solenoid cone-shaped ferrite core extensively increased the magnetic field strength (<TEX>$B_{max}=1\;T,\;{\Delta}|B|^2=220T^2/m$</TEX>) at the tip of the core and also focused the magnetic force on targeted samples. Nanoparticle contrast was demonstrated in a capillary tube filled with the SPIO solution by imaging the Doppler frequency shift which was observed independent of the flow rate and direction. Results suggest that MM-ODT may be a promising technique to enhance SPIO nanoparticle contrast for imaging fluid flow.

© 2006 Optical Society of Korea

OCIS Codes
(030.1640) Coherence and statistical optics : Coherence
(110.0110) Imaging systems : Imaging systems
(170.0170) Medical optics and biotechnology : Medical optics and biotechnology
(170.1650) Medical optics and biotechnology : Coherence imaging

History
Original Manuscript: July 11, 2006
Revised Manuscript: September 27, 2006
Published: September 25, 2006

Citation
Jee-Hyun Kim and Jung-Hwan Oh, "Nanoparticle Contrast in Magneto-Motive Optical Doppler Tomography," J. Opt. Soc. Korea 10, 99-104 (2006)
http://www.opticsinfobase.org/josk/abstract.cfm?URI=josk-10-3-99


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