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Optica Publishing Group
  • Journal of the Optical Society of Korea
  • Vol. 10,
  • Issue 3,
  • pp. 99-104
  • (2006)

Nanoparticle Contrast in Magneto-Motive Optical Doppler Tomography

Open Access Open Access

Abstract

We introduce a novel contrast mechanism for imaging superparamagnetic iron oxide (SPIO) nanoparticles (average diameter <TEX>${\sim}100nm$</TEX>) using magneto-motive optical Doppler tomography (MM-ODT), which combines an externally applied temporally oscillating high-strength magnetic field with ODT to detect the nanoparticles flowing through a glass capillary tube. A solenoid cone-shaped ferrite core extensively increased the magnetic field strength (<TEX>$B_{max}=1\;T,\;{\Delta}|B|^2=220T^2/m$</TEX>) at the tip of the core and also focused the magnetic force on targeted samples. Nanoparticle contrast was demonstrated in a capillary tube filled with the SPIO solution by imaging the Doppler frequency shift which was observed independent of the flow rate and direction. Results suggest that MM-ODT may be a promising technique to enhance SPIO nanoparticle contrast for imaging fluid flow.

© 2006 Optical Society of Korea

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