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Journal of the Optical Society of Korea

Journal of the Optical Society of Korea

| PUBLISHED BY THE OPTICAL SOCIETY OF KOREA

  • Vol. 11, Iss. 1 — Mar. 25, 2007
  • pp: 26–33

Detection of Magnetic Nanoparticles in Tissue Using Magneto-Motive DP-OCT

Jung-Hwan Oh, Ho Lee, and Jee-Hyun Kim  »View Author Affiliations


Journal of the Optical Society of Korea, Vol. 11, Issue 1, pp. 26-33 (2007)


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Abstract

We demonstrate the capability of differential-phase optical coherence tomography (DP-OCT) to detect superparamagnetic iron oxide (SPIO) nanoparticles taken up by liver parenchymeal macrophages (Kupffer cells). We apply an external time-varying high-intensity focused magnetic field. Our experiments demonstrate a novel diagnostic modality to detect macrophages that have taken up SPIO nanoparticles. Magnetic force acting on the nanoparticles was varied by applying a sinusoidal current to a solenoid containing a conical iron core that substantially increased and focused the magnetic field strength (<TEX>$B_{max}$</TEX> = 2 Tesla). <TEX>$ApoE^{-/-}$</TEX> mice were sacrificed 2 days post intravenous injections of different SPIO doses (1.0, and 0.1 mmol Fe/kg body weight). Livers of <TEX>$ApoE^{-/-}$</TEX> mice with and without injection of SPIO nanoparticles were investigated using DP-OCT, which detects tissue movement with nanometer resolution. Frequency response of iron-laden liver movement was twice the stimulus frequency. Movement was not observed in livers of control mice. Results of our experiments indicate DP-OCT is a candidate methodology to detect tissue based macrophages containing SPIO nanoparticles excited by an external focused magnetic field.

© 2007 Optical Society of Korea

OCIS Codes
(030.0030) Coherence and statistical optics : Coherence and statistical optics
(110.0110) Imaging systems : Imaging systems
(140.0140) Lasers and laser optics : Lasers and laser optics
(170.0170) Medical optics and biotechnology : Medical optics and biotechnology

History
Original Manuscript: October 23, 2006
Revised Manuscript: February 6, 2007
Published: March 25, 2007

Citation
Jung-Hwan Oh, Ho Lee, and Jee-Hyun Kim, "Detection of Magnetic Nanoparticles in Tissue Using Magneto-Motive DP-OCT," J. Opt. Soc. Korea 11, 26-33 (2007)
http://www.opticsinfobase.org/josk/abstract.cfm?URI=josk-11-1-26


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References

  1. D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and et al., "Optical coherence tomography," Science, vol. 254, pp. 1178-1181, 1991 [CrossRef]
  2. D. P. Dave and T. E. Milner, "Optical low-coherence reflectometer for differential phase measurement," Opt. Lett., vol. 25, pp. 227-229, 2000 [CrossRef]
  3. T. Akkin, D. P. Dave, T. E. Milner, and H. G. Rylander, "Detection of neural activity using phase-sensitive optical low-coherence reflectometry," Opt. Express., vol. 12, pp. 2377-2386, 2004 [CrossRef]
  4. J. I. Youn, T. Akkin, and T. E. Milner, "Electrokinetic measurement of cartilage using differential phase optical coherence tomography," Physiol. Meas., vol. 25, pp. 85-95, 2004 [CrossRef]
  5. S. A. Telenkov, D. P. Dave, S. Sethuraman, T. Akkin, and T. E. Milner, "Differential phase optical coherence probe for depth-resolved detection of photothermal response in tissue," Phys. Med. Biol., vol. 49, pp. 111- 119, 2004 [CrossRef]
  6. C. G. Rylander, D. P. Dave, T. Akkin, T. E. Milner, K. R. Diller, and A. J. Welch, "Quantitative phasecontrast imaging of cells with phase-sensitive optical coherence microscopy," Opt. Lett., vol. 29, pp. 1509- 1511, 2004 [CrossRef]
  7. R. Weissleder, D. D. Stark, B. L. Engelstad, B. R. Bacon, C. C. Compton, D. L. White, P. Jacobs, and J. Lewis, "Superparamagnetic Iron-Oxide - Pharmacokinetics and Toxicity," Am. J. Roentgenol., vol. 152, pp. 167-173, 1989
  8. P. R. Moreno, E. Falk, I. F. Palacios, J. B. Newell, V. Fuster, and J. T. Fallon, "Macrophage Infiltration in Acute Coronary Syndromes - Implications for Plaque Rupture," Circulation, vol. 90, pp. 775-778, 1994
  9. L. M. Coussens and Z. Werb,"Inflammation and cancer," Nature, vol. 420, pp. 860-867, 2002 [CrossRef]
  10. C. W. Jung and P. Jacobs, "Physical and chemical properties of superparamagnetic iron oxide MR contrast agents: ferumoxides, ferumoxtran, ferumoxsil," Magn. Reson. Imaging., vol. 13, pp. 661-674, 1995 [CrossRef]
  11. R. M. Weisskoff and S. Kiihne, "Mri Susceptometry - Image-Based Measurement of Absolute Susceptibility of Mr Contrast Agents and Human Blood," Magnet. Reson. Med., vol. 24, pp. 375-383, 1992 [CrossRef]
  12. Y. X. Wang, S. M. Hussain, and G. P. Krestin, "Superparamagnetic iron oxide contrast agents: physicochemical characteristics and applications in MR imaging," Eur. Radiol., vol. 11, pp. 2319-2331, 2001 [CrossRef]
  13. J. F. Schenck, "Safety of strong, static magnetic fields," J. Magn. Reson. Imaging., vol. 12, pp. 2-19, 2000 [CrossRef]
  14. G. Marchal, P. Van Hecke, P. Demaerel, E. Decrop, C. Kennis, A. L. Baert, and E. van der Schueren, "Detection of liver metastases with superparamagnetic iron oxide in 15 patients: results of MR imaging at 1.5 T," AJR. Am. J. Roentgenol., vol. 152, pp. 771-775, 1989
  15. P. Reimer, N. Jahnke, M. Fiebich, W. Schima, F. Deckers, C. Marx, N. Holzknecht, and S. Saini, "Hepatic lesion detection and characterization: value of nonenhanced MR imaging, superparamagnetic iron oxideenhanced MR imaging, and spiral CT-ROC analysis," Radiology, vol. 217, pp. 152-158, 2000
  16. K. Tsushima, A. Nishie, K. Yoshimitsu, A. Taketomi, and H. Honda, "Liver metastasis with apparent intratumoral superparamagnetic iron oxide uptake," Eur. Radiol., vol. 15, pp. 2203-2204, 2005 [CrossRef]
  17. R. L. Reddick, S. H. Zhang, and N. Maeda, "Atherosclerosis in Mice Lacking Apo-E - Evaluation of Lesional Development and Progression," Arterioscler. Thromb., vol. 14, pp. 839-839, 1994
  18. W. Hundt, R. Petsch, T. Helmberger, and M. Reiser, "Effect of superparamagnetic iron oxide on bone marrow," Eur. Radiol., vol. 10, pp. 1495-1500, 2000 [CrossRef]
  19. P. Cherukuri, J. Wosik, J. D. Hazle, S. Litovsky, M. Madjid, W. Casscells, J. T. Willerson, and M. Naghavi, "Contrast-enhanced intravascular detection of vulnerable plaque using superparamagnetic iron oxide and a novel magnetic resonance imaging catheter.," Am. J. Cardiol., vol. 90, pp. 23h-24h, 2002
  20. S. A. Schmitz, S. E. Coupland, R. Gust, S. Winterhalter, S. Wagner, M. Kresse, W. Semmler, and K. J. Wolf, "Superparamagnetic iron oxide-enhanced MRI of atherosclerotic plaques in Watanabe hereditable hyperlipidemic rabbits," Invest. Radiol., vol. 35, pp. 460-471, 2000 [CrossRef]
  21. T. M. Said, S. Grunewald, U. Paasch, M. Rasch, A. Agarwal, and H. J. Glander, "Effects of magneticactivated cell sorting on sperm motility and cryosurvival rates," Fertil. Steril., vol. 83, pp. 1442-1446, 2005 [CrossRef]
  22. T. Neuberger, B. Schopf, H. Hofmann, M. Hofmann, and B. von Rechenberg, "Superparamagnetic nanoparticles for biomedical applications: Possibilities and limitations of a new drug delivery system," J. Magn. Magn. Mater., vol. 293, pp. 483-496, 2005 [CrossRef]
  23. M. Chastellain, A. Petri, A. Gupta, K. V. Rao, and H. Hofmann, "Superparamagnetic silica-iron oxide nanocomposites for application in hyperthermia," Adv. Eng Mater., vol. 6, pp. 235-241, 2004 [CrossRef]
  24. G. J. Tearney, H. Yabushita, S. L. Houser, H. T. Aretz, I. K. Jang, K. H. Schlendorf, C. R. Kauffman, M. Shishkov, E. F. Halpern, and B. E. Bouma, "Quantification of macrophage content in atherosclerotic plaques by optical coherence tomography," Circulation, vol. 107, pp. 113-119, 2003 [CrossRef]
  25. A. L. Oldenburg, F. J. J. Toublan, K. S. Suslick, A. Wei, and S. A. Boppart, "Magnetomotive contrast for in vivo optical coherence tomography," Opt. Express., vol. 13, pp. 6597-6614, 2005 [CrossRef]

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