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Journal of the Optical Society of Korea

Journal of the Optical Society of Korea


  • Vol. 11, Iss. 1 — Mar. 25, 2007
  • pp: 26–33

Detection of Magnetic Nanoparticles in Tissue Using Magneto-Motive DP-OCT

Jung-Hwan Oh, Ho Lee, and Jee-Hyun Kim  »View Author Affiliations

Journal of the Optical Society of Korea, Vol. 11, Issue 1, pp. 26-33 (2007)

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We demonstrate the capability of differential-phase optical coherence tomography (DP-OCT) to detect superparamagnetic iron oxide (SPIO) nanoparticles taken up by liver parenchymeal macrophages (Kupffer cells). We apply an external time-varying high-intensity focused magnetic field. Our experiments demonstrate a novel diagnostic modality to detect macrophages that have taken up SPIO nanoparticles. Magnetic force acting on the nanoparticles was varied by applying a sinusoidal current to a solenoid containing a conical iron core that substantially increased and focused the magnetic field strength (<TEX>$B_{max}$</TEX> = 2 Tesla). <TEX>$ApoE^{-/-}$</TEX> mice were sacrificed 2 days post intravenous injections of different SPIO doses (1.0, and 0.1 mmol Fe/kg body weight). Livers of <TEX>$ApoE^{-/-}$</TEX> mice with and without injection of SPIO nanoparticles were investigated using DP-OCT, which detects tissue movement with nanometer resolution. Frequency response of iron-laden liver movement was twice the stimulus frequency. Movement was not observed in livers of control mice. Results of our experiments indicate DP-OCT is a candidate methodology to detect tissue based macrophages containing SPIO nanoparticles excited by an external focused magnetic field.

© 2007 Optical Society of Korea

OCIS Codes
(030.0030) Coherence and statistical optics : Coherence and statistical optics
(110.0110) Imaging systems : Imaging systems
(140.0140) Lasers and laser optics : Lasers and laser optics
(170.0170) Medical optics and biotechnology : Medical optics and biotechnology

Original Manuscript: October 23, 2006
Revised Manuscript: February 6, 2007
Published: March 25, 2007

Jung-Hwan Oh, Ho Lee, and Jee-Hyun Kim, "Detection of Magnetic Nanoparticles in Tissue Using Magneto-Motive DP-OCT," J. Opt. Soc. Korea 11, 26-33 (2007)

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