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Journal of the Optical Society of Korea

Journal of the Optical Society of Korea


  • Vol. 12, Iss. 2 — Jun. 25, 2008
  • pp: 98–102

Evaluation of Morphological Changes in Degenerative Cartilage Using 3-D Optical Coherence Tomography

Jong-In Youn  »View Author Affiliations

Journal of the Optical Society of Korea, Vol. 12, Issue 2, pp. 98-102 (2008)

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Optical Coherence Tomography (OCT) is an important noninvasive medical imaging technique that can reveal subsurface structures of biological tissue. OCT has demonstrated a good correlation with histology in sufficient resolution to identify morphological changes in articular cartilage to differentiate normal through progressive stages of degenerative joint disease. Current OCT systems provide individual cross-sectional images that are representative of the tissue directly under the scanning beam, but they may not fully demonstrate the degree of degeneration occurring within a region of a joint surface. For a full understanding of the nature and degree of cartilage degeneration within a joint, multiple OCT images must be obtained and an overall assessment of the joint surmised from multiple individual images. This study presents frequency domain three-dimensional (3-D) OCT imaging of degenerative joint cartilage extracted from bovine knees. The 3-D OCT imaging of articular cartilage enables the assembly of 126 individual, adjacent, rapid scanned OCT images into a full 3-D image representation of the tissue scanned, or these may be viewed in a progression of successive individual two-dimensional (2-D) OCT images arranged in 3-D orientation. A fiber-based frequency domain OCT system that provides cross-sectional images was used to acquire 126 successive adjacent images for a sample volume of <TEX>$6{\times}3.2{\times}2.5\;mm^3$</TEX>. The axial resolution was <TEX>$8\;{\mu}m$</TEX> in air. The 3-D OCT was able to demonstrate surface topography and subsurface disruption of articular cartilage consistent with the gross image as well as with histological cross-sections of the specimen. The 3-D OCT volumetric imaging of articular cartilage provides an enhanced appreciation and better understanding of regional degenerative joint disease than may be realized by individual 2-D OCT sectional images.

© 2008 Optical Society of Korea

OCIS Codes
(170.0170) Medical optics and biotechnology : Medical optics and biotechnology
(170.1610) Medical optics and biotechnology : Clinical applications
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.4500) Medical optics and biotechnology : Optical coherence tomography
(170.4580) Medical optics and biotechnology : Optical diagnostics for medicine

Original Manuscript: April 7, 2008
Revised Manuscript: April 15, 2008
Manuscript Accepted: April 16, 2008
Published: June 25, 2008

Jong-In Youn, "Evaluation of Morphological Changes in Degenerative Cartilage Using 3-D Optical Coherence Tomography," J. Opt. Soc. Korea 12, 98-102 (2008)

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