OSA's Digital Library

Journal of the Optical Society of Korea

Journal of the Optical Society of Korea

| PUBLISHED BY THE OPTICAL SOCIETY OF KOREA

  • Vol. 12, Iss. 2 — Jun. 25, 2008
  • pp: 98–102

Evaluation of Morphological Changes in Degenerative Cartilage Using 3-D Optical Coherence Tomography

Jong-In Youn  »View Author Affiliations


Journal of the Optical Society of Korea, Vol. 12, Issue 2, pp. 98-102 (2008)


View Full Text Article

Acrobat PDF (1358 KB)





Browse Journals / Lookup Meetings

Browse by Journal and Year


   


Lookup Conference Papers

Close Browse Journals / Lookup Meetings

Article Tools

Share
Citations
  • Export Citation/Save Click for help

Abstract

Optical Coherence Tomography (OCT) is an important noninvasive medical imaging technique that can reveal subsurface structures of biological tissue. OCT has demonstrated a good correlation with histology in sufficient resolution to identify morphological changes in articular cartilage to differentiate normal through progressive stages of degenerative joint disease. Current OCT systems provide individual cross-sectional images that are representative of the tissue directly under the scanning beam, but they may not fully demonstrate the degree of degeneration occurring within a region of a joint surface. For a full understanding of the nature and degree of cartilage degeneration within a joint, multiple OCT images must be obtained and an overall assessment of the joint surmised from multiple individual images. This study presents frequency domain three-dimensional (3-D) OCT imaging of degenerative joint cartilage extracted from bovine knees. The 3-D OCT imaging of articular cartilage enables the assembly of 126 individual, adjacent, rapid scanned OCT images into a full 3-D image representation of the tissue scanned, or these may be viewed in a progression of successive individual two-dimensional (2-D) OCT images arranged in 3-D orientation. A fiber-based frequency domain OCT system that provides cross-sectional images was used to acquire 126 successive adjacent images for a sample volume of <TEX>$6{\times}3.2{\times}2.5\;mm^3$</TEX>. The axial resolution was <TEX>$8\;{\mu}m$</TEX> in air. The 3-D OCT was able to demonstrate surface topography and subsurface disruption of articular cartilage consistent with the gross image as well as with histological cross-sections of the specimen. The 3-D OCT volumetric imaging of articular cartilage provides an enhanced appreciation and better understanding of regional degenerative joint disease than may be realized by individual 2-D OCT sectional images.

© 2008 Optical Society of Korea

OCIS Codes
(170.0170) Medical optics and biotechnology : Medical optics and biotechnology
(170.1610) Medical optics and biotechnology : Clinical applications
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.4500) Medical optics and biotechnology : Optical coherence tomography
(170.4580) Medical optics and biotechnology : Optical diagnostics for medicine

History
Original Manuscript: April 7, 2008
Revised Manuscript: April 15, 2008
Manuscript Accepted: April 16, 2008
Published: June 25, 2008

Citation
Jong-In Youn, "Evaluation of Morphological Changes in Degenerative Cartilage Using 3-D Optical Coherence Tomography," J. Opt. Soc. Korea 12, 98-102 (2008)
http://www.opticsinfobase.org/josk/abstract.cfm?URI=josk-12-2-98


Sort:  Year  |  Journal  |  Reset

References

  1. V. C. Mow, Injury and repair of the musculoskeletal soft tissues, (American Academy of Orthopaedic Surgeons, 1988.)
  2. H. J. Mankin, H. Dorfman, L. Lippiello, and A. Zarins, “Biochemical and metabolic abnormalities in articular cartilage from osteo-arthritic human hips. II. Correlation of morphology with biochemical and metabolic data,” J. Bone Jt. Surg. Am.. vol. 53, pp. 523-537, 1971
  3. J. M. Herrmann, C. Pitris, B. E. Bouma, S. A. Boppart, C. A. Jesser, D. L. Stamper, et al., “High resolution imaging of normal and osteoarthritic cartilage with optical coherence tomography,” J. Rheumatol. vol. 26, pp. 627-635, 1999
  4. C. W. Han, C. R. Chu, N. Adachi, A. Usas, F. H. Fu, J. Huard, et al., “Analysis of rabbit articular cartilage repair after chondrocyte implantation using optical coherence tomography,” Osteoarthritis and Cartilage, vol. 11, pp. 111-121, 2003 [CrossRef]
  5. J. Rogowska, C. M. Bryant, and M. E. Brezinski, “Cartilage thickness measurements from optical coherence tomorgraphy,” Opt. Soc. Am. A, vol. 20, no. 2, pp. 357-367, 2003 [CrossRef]
  6. M. J. Roberts, S. B. Adams, N. A. Patel, D. L. Stampler, M. S. Westmore, S. D. Martin, et al., “A new approach for assessing early osteoarthiritis in the rat,” Anal. Bioanal. Chem., vol. 377, pp. 1003-1006, 2003 [CrossRef]
  7. Y. Pan, Z. Li, T. Xie, and C. R. Chu, “Hand-held arthroscopic optical coherence tomography for in-vivo high-resolution imaging of articular cartilage,” J. Biomed. Opt., vol. 8, no. 4, pp. 648-654, 2003 [CrossRef]
  8. C. R. Chu, D. Lin, J. L. Geisler, C. T. Chu, F. H. Fu, and Y. Pan, “Arthroscopic microscopy of articular cartilage using optical coherence tomography,” Am. Orthopaedic Society for Sports Medicine., vol.32, no.3, pp. 699-709, 2004
  9. X. D. Li, S. Martin, C. Pitris, R. Ghanta, D. L. Stamper, M. Harman, J. G. Fujimoto, and M. E. Brezinski, “High-resolution optical coherence tomographic imaging of osteoarthritic cartilage during open knee surgery,” Arthritis Res. & Ther., vol. 7, no. 2, pp. 318-323, 2005 [CrossRef]

Cited By

OSA is able to provide readers links to articles that cite this paper by participating in CrossRef's Cited-By Linking service. CrossRef includes content from more than 3000 publishers and societies. In addition to listing OSA journal articles that cite this paper, citing articles from other participating publishers will also be listed.

« Previous Article  |  Next Article »

OSA is a member of CrossRef.

CrossCheck Deposited