In coherent anti-Stokes Raman scattering (CARS) microscopy reported until now, conventional microscope objectives are used, so that they are limited for introduction into a living body. Gradient-index (GRIN) rod lenses might be a solution for miniaturized microscope objectives for in-vivo CARS microscopy. However, due to the inherent large amount of chromatic aberration, GRIN rod lenses cannot be utilized for this purpose. CARS imaging catheter, composed of miniaturized microscope objective and fiber bundle, can be introduced into a living body for minimally invasive diagnosis. In order to design the catheter, we have to first investigate design requirements. And then, the optical design is processed with design strategies and intensive computing power to achieve the design requirements. We report the miniaturized objective lens system with diffraction-limited performance and completely corrected chromatic aberrations for an in-vivo CARS imaging catheter.
© 2010 Optical Society of Korea
(110.0180) Imaging systems : Microscopy
(220.0220) Optical design and fabrication : Optical design and fabrication
(220.3620) Optical design and fabrication : Lens system design
(300.6230) Spectroscopy : Spectroscopy, coherent anti-Stokes Raman scattering
Original Manuscript: August 3, 2010
Revised Manuscript: September 16, 2010
Manuscript Accepted: September 29, 2010
Published: December 25, 2010
Cheon-Seog Rim, "The Optical Design of Miniaturized Microscope Objective for CARS Imaging Catheter with Fiber Bundle," J. Opt. Soc. Korea 14, 424-430 (2010)
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