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Journal of the Optical Society of Korea

Journal of the Optical Society of Korea


  • Vol. 15, Iss. 2 — Jun. 1, 2011
  • pp: 155–160

Terahertz Pulse Imaging of Micro-metastatic Lymph Nodes in Early-stage Cervical Cancer Patients

Eun-A Jung, Mee-Hyun Lim, Ki-Won Moon, Young-Woong Do, Soon-Sung Lee, Hae-Wook Han, Hyuck-Jae Choi, Kyoung-Sik Cho, and Kyu-Rae Kim  »View Author Affiliations

Journal of the Optical Society of Korea, Vol. 15, Issue 2, pp. 155-160 (2011)

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Lymph node metastasis is an important prognostic factor in cervical cancer patients. We report THz imaging for detecting micro-metastatic foci in the lymph nodes of early-stage uterine cervical cancer patients. Five paraffin-embedded metastatic lymph nodes from two cervical cancer patients were imaged using a THz time-domain spectroscopy system in the reflection mode. The size and shape of the tumor regions were compared with those from histopathologic examinations. The metastatic portions of lymph nodes as small as 3 mm were well delineated by THz imaging. The reflected peak amplitudes were lower in metastatic portions than in the normal portions of lymph nodes, and the difference in their peak-to-peak amplitudes was ~5%.

© 2011 Optical Society of Korea

OCIS Codes
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(300.6495) Spectroscopy : Spectroscopy, teraherz
(110.6795) Imaging systems : Terahertz imaging

Original Manuscript: March 2, 2011
Revised Manuscript: March 18, 2011
Manuscript Accepted: March 18, 2011
Published: June 25, 2011

Eun-A Jung, Mee-Hyun Lim, Ki-Won Moon, Young-Woong Do, Soon-Sung Lee, Hae-Wook Han, Hyuck-Jae Choi, Kyoung-Sik Cho, and Kyu-Rae Kim, "Terahertz Pulse Imaging of Micro-metastatic Lymph Nodes in Early-stage Cervical Cancer Patients," J. Opt. Soc. Korea 15, 155-160 (2011)

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