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Journal of the Optical Society of Korea

Journal of the Optical Society of Korea

| PUBLISHED BY THE OPTICAL SOCIETY OF KOREA

  • Vol. 17, Iss. 4 — Aug. 1, 2013
  • pp: 289–295

Development of an Optical Tissue Clearing Laser Probe System

Changmin Yeo, Heesung Kang, Yunjin Bae, Jihoon Park, J. Stuart Nelson, Kyoung-Joung Lee, and Byungjo Jung  »View Author Affiliations


Journal of the Optical Society of Korea, Vol. 17, Issue 4, pp. 289-295 (2013)


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Abstract

Although low-level laser therapy (LLLT) has been a valuable therapeutic technology in the clinic, its efficacy may be reduced in deep tissue layers due to strong light scattering which limits the photon density. In order to enhance the photon density in deep tissue layers, this study developed an optical tissue clearing (OTC) laser probe (OTCLP) system which can utilize four different OTC methods: 1) tissue temperature control from 40 to <TEX>$10^{\circ}C$</TEX>; 2) laser pulse frequency from 5 to 30 Hz; 3) glycerol injection at a local region; and 4) a combination of the aforementioned three methods. The efficacy of the OTC methods was evaluated and compared by investigating laser beam profiles in ex-vivo porcine skin samples. Results demonstrated that total (peak) intensity at full width at half maximum of laser beam profile when compared to control data was increased: 1) 1.21(1.39)-fold at <TEX>$10^{\circ}C$</TEX>; 2) 1.22 (1.49)-fold at a laser pulse frequency of 5 Hz; 3) 1.64 (2.41)-fold with 95% glycerol injection; 4) 1.86 (3.4)-fold with the combination method. In conclusion, the OTCLP system successfully improved the laser photon density in deep tissue layers and may be utilized as a useful tool in LLLT by increasing laser photon density.

© 2013 Optical Society of Korea

OCIS Codes
(000.2170) General : Equipment and techniques
(120.4820) Instrumentation, measurement, and metrology : Optical systems
(170.1610) Medical optics and biotechnology : Clinical applications
(350.4600) Other areas of optics : Optical engineering

History
Original Manuscript: April 12, 2013
Revised Manuscript: August 6, 2013
Manuscript Accepted: August 6, 2013
Published: August 25, 2013

Citation
Changmin Yeo, Heesung Kang, Yunjin Bae, Jihoon Park, J. Stuart Nelson, Kyoung-Joung Lee, and Byungjo Jung, "Development of an Optical Tissue Clearing Laser Probe System," J. Opt. Soc. Korea 17, 289-295 (2013)
http://www.opticsinfobase.org/josk/abstract.cfm?URI=josk-17-4-289


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