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Journal of the Optical Society of Korea

Journal of the Optical Society of Korea

| PUBLISHED BY THE OPTICAL SOCIETY OF KOREA

  • Vol. 7, Iss. 4 — Dec. 25, 2003
  • pp: 230–233

Conceptual Design of Soft X-ray Microscopy for Live Biological Samples

Kyong-Woo Kim, Ki-Yong Nam, Young-Man Kwon, Seong-Taek Shim, Kyu-Gyeom Kim, and Kwon-Ha Yoon  »View Author Affiliations


Journal of the Optical Society of Korea, Vol. 7, Issue 4, pp. 230-233 (2003)


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Abstract

This study describes the conceptual design of a soft x-ray microscope system based on a laserbased source for biomedical application with high resolution (<TEX>${\leq}$</TEX>50nm). The laboratory scale soft x-ray microscope consists of high power laser plasma x-ray source and grazing incidence mirrors with high reflectivity. The laser plasma source used for developing this system employs Q-switched Nd-YAG pulsed laser. The laser beam is focused on a tantalum (Ta) target. The Wolter type I mirror was used as condenser optics for sample illumination and as objective mirror for focusing on a detector. The fabrication of the Wolter type I mirror was direct internal cutting using ultraprecision DTM. A hydrated biological specimen was put between the two silicon wafers, the center of which was <TEX>$Si_3N_4$</TEX> windows of 100㎚ thickness. The main issues in the future development work are to make a stable, reliable and reproducible x-ray microscope system.

© 2003 Optical Society of Korea

OCIS Codes
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.7440) Medical optics and biotechnology : X-ray imaging
(180.7460) Microscopy : X-ray microscopy
(340.7460) X-ray optics : X-ray microscopy

History
Original Manuscript: September 25, 2003
Published: December 1, 2003

Citation
Kyong-Woo Kim, Ki-Yong Nam, Young-Man Kwon, Seong-Taek Shim, Kyu-Gyeom Kim, and Kwon-Ha Yoon, "Conceptual Design of Soft X-ray Microscopy for Live Biological Samples," J. Opt. Soc. Korea 7, 230-233 (2003)
http://www.opticsinfobase.org/josk/abstract.cfm?URI=josk-7-4-230


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References

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