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Optics Express

Optics Express

  • Editor: Michael Duncan
  • Vol. 12, Iss. 15 — Jul. 26, 2004
  • pp: 3532–3542

Ultrahigh resolution optical biopsy with endoscopic optical coherence tomography

Paul R. Herz, Yu Chen, Aaron D. Aguirre, James G. Fujimoto, Hiroshi Mashimo, Joseph Schmitt, Amanda Koski, John Goodnow, and Chris Petersen  »View Author Affiliations

Optics Express, Vol. 12, Issue 15, pp. 3532-3542 (2004)

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Optical coherence tomography (OCT) is an emerging medical imaging technology that can generate high resolution, cross-sectional images of tissue in situ and in real time. Although endoscopic OCT has been used successfully to identify certain pathologies in the gastrointestinal tract, the resolution of current endoscopic OCT systems has been limited to 10–15 µm for in vivo studies. In this study, in vivo imaging of the rabbit gastrointestinal tract is demonstrated at a three-fold higher resolution (<5 µm), using a broadband Cr4+:Forsterite laser as the optical light source. Images acquired from the esophagus, trachea, and colon reveal high-resolution details of tissue architecture. Definitive correlation of architectural features in OCT images and histological sections is shown. The ability of ultrahigh resolution endoscopic OCT to image tissue morphology at an unprecedented resolution in vivo advances the development of OCT as a potential imaging tool for the early detection of neoplastic changes in biological tissue.

© 2004 Optical Society of America

OCIS Codes
(170.2150) Medical optics and biotechnology : Endoscopic imaging
(170.4500) Medical optics and biotechnology : Optical coherence tomography

ToC Category:
Research Papers

Original Manuscript: June 7, 2004
Revised Manuscript: July 15, 2004
Published: July 26, 2004

Paul Herz, Yu Chen, Aaron Aguirre, James Fujimoto, Hiroshi Mashimo, Joseph Schmitt, Amanda Koski, John Goodnow, and Chris Petersen, "Ultrahigh resolution optical biopsy with endoscopic optical coherence tomography," Opt. Express 12, 3532-3542 (2004)

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