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Optics Express

Optics Express

  • Editor: Michael Duncan
  • Vol. 12, Iss. 13 — Jun. 28, 2004
  • pp: 2966–2971

Theoretical study of immersion optical clearing of blood in vessels at local hemolysis

Valery V. Tuchin, Dmitry M. Zhestkov, Alexey N. Bashkatov, and Elina A. Genina  »View Author Affiliations


Optics Express, Vol. 12, Issue 13, pp. 2966-2971 (2004)
http://dx.doi.org/10.1364/OPEX.12.002966


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Abstract

Mie based theoretical analysis has been performed for investigation of the possibility of application of the plasma hemoglobin releasing due to local hemolysis for optical clearing of blood. The 30–40% reduction of the scattering coefficient of blood in the spectral range from 400 to 1000 nm with increase of degree of hemolysis (up to 20%) was shown. At the same time, the reduction of absorption coefficient of blood is localized mainly within the Soret band with maximum at 415 nm (~15%), the α-band at 540 nm and the β-band at 577 nm (~10%) of oxyhemoglobin. In the spectral range from 700 to 1000 nm the decrease of absorption coefficient is less than 8%.

© 2004 Optical Society of America

OCIS Codes
(000.1430) General : Biology and medicine
(170.1470) Medical optics and biotechnology : Blood or tissue constituent monitoring
(290.5850) Scattering : Scattering, particles
(290.7050) Scattering : Turbid media

ToC Category:
Research Papers

History
Original Manuscript: April 5, 2004
Revised Manuscript: May 13, 2004
Published: June 28, 2004

Citation
Valery Tuchin, Dmitry Zhestkov, Alexey Bashkatov, and Elina Genina, "Theoretical study of immersion optical clearing of blood in vessels at local hemolysis," Opt. Express 12, 2966-2971 (2004)
http://www.opticsinfobase.org/oe/abstract.cfm?URI=oe-12-13-2966


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