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Optics Express

Optics Express

  • Editor: Michael Duncan
  • Vol. 12, Iss. 3 — Feb. 9, 2004
  • pp: 367–376

In vivo high-resolution video-rate spectral-domain optical coherence tomography of the human retina and optic nerve

N. A. Nassif, B. Cense, B. H. Park, M. C. Pierce, S. H. Yun, B. E. Bouma, G. J. Tearney, T. C. Chen, and J. F. de Boer  »View Author Affiliations


Optics Express, Vol. 12, Issue 3, pp. 367-376 (2004)
http://dx.doi.org/10.1364/OPEX.12.000367


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Abstract

An ultra-high-speed spectral-domain optical coherence tomography system (SD-OCT) was developed for imaging the human retina and optic nerve in vivo at a sustained depth profile (A-line) acquisition speed of 29 kHz. The axial resolution was 6 µm in tissue and the system had shot-noise-limited performance with a maximum sensitivity of 98.4 dB. 3-dimensional data sets were collected in 11 and 13 seconds for the macula and optic nerve head respectively and are presented to demonstrate the potential clinical applications of SD-OCT in ophthalmology. Additionally, a 3-D volume of the optic nerve head was constructed from the acquired data and the retinal vascular network was visualized.

© 2004 Optical Society of America

OCIS Codes
(030.4280) Coherence and statistical optics : Noise in imaging systems
(110.4280) Imaging systems : Noise in imaging systems
(110.4500) Imaging systems : Optical coherence tomography
(110.6880) Imaging systems : Three-dimensional image acquisition
(170.3890) Medical optics and biotechnology : Medical optics instrumentation
(170.4470) Medical optics and biotechnology : Ophthalmology

ToC Category:
Research Papers

History
Original Manuscript: December 19, 2003
Revised Manuscript: January 14, 2004
Published: February 9, 2004

Citation
N. Nassif, B. Cense, B. Park, M. Pierce, S. Yun, B. Bouma, G. Tearney, T. Chen, and J. de Boer, "In vivo high-resolution video-rate spectral-domain optical coherence tomography of the human retina and optic nerve," Opt. Express 12, 367-376 (2004)
http://www.opticsinfobase.org/oe/abstract.cfm?URI=oe-12-3-367


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References

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