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Optics Express

Optics Express

  • Editor: Michael Duncan
  • Vol. 13, Iss. 12 — Jun. 13, 2005
  • pp: 4611–4628

Form-biattenuance in fibrous tissues measured with polarization-sensitive optical coherence tomography (PS-OCT)

Nate J. Kemp, Haitham N. Zaatari, Jesung Park, H. Grady Rylander III, and Thomas E. Milner  »View Author Affiliations


Optics Express, Vol. 13, Issue 12, pp. 4611-4628 (2005)
http://dx.doi.org/10.1364/OPEX.13.004611


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Abstract

Form-biattenuance (Δχ) in biological tissue arises from anisotropic light scattering by regularly oriented cylindrical fibers and results in a differential attenuation (diattenuation) of light amplitudes polarized parallel and perpendicular to the fiber axis (eigenpolarizations). Form-biattenuance is complimentary to form-birefringence (Δn) which results in a differential delay (phase retardation) between eigenpolarizations. We justify the terminology and motivate the theoretical basis for form-biattenuance in depth-resolved polarimetry. A technique to noninvasively and accurately quantify form-biattenuance which employs a polarization-sensitive optical coherence tomography (PS-OCT) instrument in combination with an enhanced sensitivity algorithm is demonstrated on ex vivo rat tail tendon (mean Δχ=5.3·10-4, N=111), rat Achilles tendon (Δχ=1.3·10-4, N=45), chicken drumstick tendon (Δχ=2.1·10-4, N=57), and in vivo primate retinal nerve fiber layer (Δχ=0.18·10-4, N=6). A physical model is formulated to calculate the contributions of Δχ and Δn to polarimetric transformations in anisotropic media.

© 2005 Optical Society of America

OCIS Codes
(030.6140) Coherence and statistical optics : Speckle
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.4500) Medical optics and biotechnology : Optical coherence tomography
(260.1440) Physical optics : Birefringence
(260.5430) Physical optics : Polarization

ToC Category:
Research Papers

History
Original Manuscript: March 22, 2005
Revised Manuscript: April 22, 2005
Published: June 13, 2005

Citation
Nate Kemp, Haitham Zaatari, Jesung Park, H. Grady Rylander III, and Thomas Milner, "Form-biattenuance in fibrous tissues measured with polarization-sensitive optical coherence tomography (PS-OCT)," Opt. Express 13, 4611-4628 (2005)
http://www.opticsinfobase.org/oe/abstract.cfm?URI=oe-13-12-4611


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